Version 5.4
Mus musculus Gene: G3bp1
Summary
InnateDB Gene IDBG-175322.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol G3bp1
Gene Name Ras-GTPase-activating protein SH3-domain binding protein 1
Synonyms AI849976; B430204O07; C87777; G3bp; mKIAA4115
Species Mus musculus
Ensembl Gene ENSMUSG00000018583
Encoded Proteins
IDBP-175326
Ras-GTPase-activating protein SH3-domain binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25520508
[Homo sapiens] EIF2AK2 (PKR) is recruited to stress granules by G3BP1 to promote innate immune responses at both transcriptional and translational levels.
PMID 25784705
[Homo sapiens] The G3BP1-CAPRIN1-PRKRA complex represents a new mode of PRKRA activation and links stress responses with innate immune activation through PRKRA without a requirement for foreign double-stranded RNA pattern recognition.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145907:
This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3\'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:55469685-55504838
Strand Forward strand
Band B1.3
Transcripts
ENSMUST00000018727 ENSMUSP00000018727
ENSMUST00000151790
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 3 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 74 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003729 mRNA binding
GO:0004386 helicase activity
GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006810 transport
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010494 cytoplasmic stress granule
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145907
View Gene Order
ENSBTAG00000020309
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt P97855
TrEMBL Q571F9
UniProt Splice Variant
Entrez Gene 27041
UniGene Mm.380129 Mm.39631 Mm.405739
RefSeq NM_013716 XM_006533444
OMIM
CCDS CCDS24714
HPRD
IMGT
MGI ID MGI:1351465
MGI Symbol G3bp1
EMBL AB001927 AK220230 BC021156
GenPept AAH21156 BAA19469 BAD90155
RNA Seq Atlas 27041

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca