InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adra1a

Summary

InnateDB Gene

IDBG-175481.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adra1a

Gene Name

adrenergic receptor, alpha 1a

Synonyms

Adra1c

Species

Mus musculus

Ensembl Gene

ENSMUSG00000045875

Encoded Proteins

IDBP-175483

adrenergic receptor, alpha 1a

IDBP-538611

adrenergic receptor, alpha 1a

IDBP-541490

adrenergic receptor, alpha 1a

IDBP-532939

adrenergic receptor, alpha 1a

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes one of several multipass transmembrane proteins that function as G protein-coupled receptors. The encoded protein binds to epinephrine and norepinephrine to mediate signaling in cells of the cardiac, nervous, and other organ systems. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:66635251-66733462

Strand

Forward strand

Band

Transcripts

ENSMUST00000054661	ENSMUSP00000053703
ENSMUST00000159365	ENSMUSP00000124322
ENSMUST00000160647
ENSMUST00000159068	ENSMUSP00000124570
ENSMUST00000161339	ENSMUSP00000125354

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004937	alpha1-adrenergic receptor activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001985	negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0003084	positive regulation of systemic arterial blood pressure
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007512	adult heart development
GO:0007568	aging
GO:0009725	response to hormone
GO:0010460	positive regulation of heart rate
GO:0016049	cell growth
GO:0019229	regulation of vasoconstriction
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0035024	negative regulation of Rho protein signal transduction
GO:0035265	organ growth
GO:0042493	response to drug
GO:0043410	positive regulation of MAPK cascade
GO:0045760	positive regulation of action potential
GO:0045907	positive regulation of vasoconstriction
GO:0045987	positive regulation of smooth muscle contraction
GO:0055117	regulation of cardiac muscle contraction
GO:0060073	micturition
GO:0060402	calcium ion transport into cytosol
GO:0060452	positive regulation of cardiac muscle contraction
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071875	adrenergic receptor signaling pathway
GO:0090037	positive regulation of protein kinase C signaling
GO:0097195	pilomotor reflex

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030018	Z disc
GO:0030315	T-tubule
GO:0031965	nuclear membrane