Mus musculus Gene: Smad6
Summary
InnateDB Gene IDBG-175757.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smad6
Gene Name SMAD family member 6
Synonyms b2b390Clo; Madh6;
Species Mus musculus
Ensembl Gene ENSMUSG00000036867
Encoded Proteins
MAD homolog 6 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] SMAD6 is a critical mediator of the TGF-beta-BMP pathway that mediates anti-inflammatory activity and negatively regulates IL-1R-Toll-like receptor signals.
[Homo sapiens] SMAD6 acts a critical mediator for effective TGF-beta1-mediated suppression of IL-1R/TLR signalling, by simultaneous binding to discrete regions of Pellino-1.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137834:
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila \'mothers against decapentaplegic\' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:63953076-64022059
Strand Reverse strand
Band C
Transcripts
ENSMUST00000041029 ENSMUSP00000036285
ENSMUST00000144323
ENSMUST00000179458 ENSMUSP00000137442
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0031625 ubiquitin protein ligase binding
GO:0034713 type I transforming growth factor beta receptor binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
GO:0070410 co-SMAD binding
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
GO:0070698 type I activin receptor binding
Biological Process
GO:0001657 ureteric bud development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006955 immune response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007352 zygotic specification of dorsal/ventral axis
GO:0008285 negative regulation of cell proliferation
GO:0010991 negative regulation of SMAD protein complex assembly
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0031589 cell-substrate adhesion
GO:0034616 response to laminar fluid shear stress
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
GO:0043627 response to estrogen
GO:0045444 fat cell differentiation
GO:0045907 positive regulation of vasoconstriction
GO:0045908 negative regulation of vasodilation
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060948 cardiac vascular smooth muscle cell development
GO:0060977 coronary vasculature morphogenesis
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by BMP pathway
Signal Transduction pathway
KEGG
Endocytosis pathway
TGF-beta signaling pathway pathway
INOH
BMP2 signaling pathway
TGF-beta signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TGF_beta_Receptor pathway
REACTOME
Signal Transduction pathway
Signaling by BMP pathway
KEGG
Endocytosis pathway
TGF-beta signaling pathway pathway
INOH
TGF-beta signaling pathway
BMP2 signaling pathway
PID BIOCARTA
Ctcf: first multivalent nuclear factor [Biocarta view]
Alk in cardiac myocytes [Biocarta view]
PID NCI
BMP receptor signaling
Cross-References
SwissProt O35182
TrEMBL J3QPR3
UniProt Splice Variant
Entrez Gene 17130
UniGene Mm.325757 Mm.412887
RefSeq NM_008542 XM_006510822
OMIM
CCDS CCDS23273
HPRD
IMGT
MGI ID MGI:1336883
MGI Symbol Smad6
EMBL AC114674 AC135672 AF010133 AK004671
GenPept AAB81351 BAB23460
RNA Seq Atlas 17130