Mus musculus Gene: Oaz1
Summary
InnateDB Gene IDBG-176253.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Oaz1
Gene Name ornithine decarboxylase antizyme 1
Synonyms Antizyme; AZ-1; AZ1; Oaz; ODC-Az;
Species Mus musculus
Ensembl Gene ENSMUSG00000035242
Encoded Proteins
ornithine decarboxylase antizyme 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase and accelerates its degradation. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as by inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization (PMID:16120325). Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:80826656-80829290
Strand Forward strand
Band C1
Transcripts
ENSMUST00000060987 ENSMUSP00000055922
ENSMUST00000180036 ENSMUSP00000137400
ENSMUST00000179620 ENSMUSP00000136134
ENSMUST00000179341 ENSMUSP00000136251
ENSMUST00000177850 ENSMUSP00000136469
ENSMUST00000179894
ENSMUST00000179172 ENSMUSP00000136186
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0005515 protein binding
GO:0008073 ornithine decarboxylase inhibitor activity
Biological Process
GO:0006595 polyamine metabolic process
GO:0043086 negative regulation of catalytic activity
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Regulation of ornithine decarboxylase (ODC) pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of amino acids and derivatives pathway
Regulation of ornithine decarboxylase (ODC) pathway
Metabolism pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Aurora A signaling
Cross-References
SwissProt
TrEMBL J3QM60
UniProt Splice Variant
Entrez Gene 18245
UniGene Mm.467755
RefSeq NM_008753
OMIM
CCDS CCDS56736
HPRD
IMGT
MGI ID MGI:109433
MGI Symbol Oaz1
EMBL AC166937
GenPept
RNA Seq Atlas 18245