Version 5.4
Mus musculus Gene: Pak3
Summary
InnateDB Gene IDBG-176809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pak3
Gene Name p21 protein (Cdc42/Rac)-activated kinase 3
Synonyms PAK-3; Pak65alpha; Pak65beta; Stk4
Species Mus musculus
Ensembl Gene ENSMUSG00000031284
Encoded Proteins
IDBP-176811
p21 protein (Cdc42/Rac)-activated kinase 3
IDBP-255066
p21 protein (Cdc42/Rac)-activated kinase 3
IDBP-255068
p21 protein (Cdc42/Rac)-activated kinase 3
IDBP-255070
p21 protein (Cdc42/Rac)-activated kinase 3
IDBP-255072
p21 protein (Cdc42/Rac)-activated kinase 3
IDBP-536533
p21 protein (Cdc42/Rac)-activated kinase 3
IDBP-541499
p21 protein (Cdc42/Rac)-activated kinase 3
IDBP-537704
p21 protein (Cdc42/Rac)-activated kinase 3
IDBP-532920
p21 protein (Cdc42/Rac)-activated kinase 3
IDBP-624860
p21 protein (Cdc42/Rac)-activated kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077264:
PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:143518591-143797796
Strand Forward strand
Band F2
Transcripts
ENSMUST00000033640 ENSMUSP00000033640
ENSMUST00000112868 ENSMUSP00000108489
ENSMUST00000112865 ENSMUSP00000108486
ENSMUST00000112864 ENSMUSP00000108485
ENSMUST00000112863 ENSMUSP00000108484
ENSMUST00000134402 ENSMUSP00000119090
ENSMUST00000126592 ENSMUSP00000114352
ENSMUST00000156449 ENSMUSP00000118716
ENSMUST00000155215 ENSMUSP00000118549
ENSMUST00000172330 ENSMUSP00000126562
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017048 Rho GTPase binding
GO:0017124 SH3 domain binding
GO:0046872 metal ion binding
GO:0051020 GTPase binding
Biological Process
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0006468 protein phosphorylation
GO:0007015 actin filament organization
GO:0007409 axonogenesis
GO:0010975 regulation of neuron projection development
GO:0016358 dendrite development
GO:0023014 signal transduction by phosphorylation
GO:0030036 actin cytoskeleton organization
GO:0030833 regulation of actin filament polymerization
GO:0035556 intracellular signal transduction
GO:0043525 positive regulation of neuron apoptotic process
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:2000573 positive regulation of DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000077264
View Gene Order
ENSBTAG00000015670
Not yet available
Pathways
NETPATH
REACTOME
REACT_227951
Signaling by VEGF pathway
REACT_254306
Sema3A PAK dependent Axon repulsion pathway
REACT_230745
Immune System pathway
REACT_221567
Signaling by Robo receptor pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_261451
CD28 dependent Vav1 pathway pathway
REACT_204081
CD28 co-stimulation pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_261840
VEGFR2 mediated vascular permeability pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_229531
Adaptive Immune System pathway
REACT_188576
Developmental Biology pathway
REACT_241951
Ephrin signaling pathway
REACT_263034
Semaphorin interactions pathway
REACT_188257
Signal Transduction pathway
REACT_225768
Generation of second messenger molecules pathway
REACT_260744
Activation of Rac pathway
REACT_222648
TCR signaling pathway
KEGG
mmu04360
Axon guidance pathway
mmu05211
Renal cell carcinoma pathway
mmu04012
ErbB signaling pathway pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04510
Focal adhesion pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12623
Generation of second messenger molecules pathway
REACT_19238
CD28 dependent Vav1 pathway pathway
REACT_19183
CD28 co-stimulation pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_19236
Sema3A PAK dependent Axon repulsion pathway
REACT_19226
Activation of Rac pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_111045
Developmental Biology pathway
REACT_12526
TCR signaling pathway
REACT_19271
Semaphorin interactions pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_18266
Axon guidance pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228226
Ephrin signaling pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_163701
FCERI mediated MAPK activation pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04360
Axon guidance pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A3KGC2 A3KGC3
UniProt Splice Variant
Entrez Gene 18481
UniGene Mm.40035 Mm.474844
RefSeq NM_001195046 NM_001195047 NM_001195048 NM_001195049 NM_008778 XM_006528747 XM_006528748 XM_006528749 XM_006528750 XM_006528751 XM_006528752 XM_006528753 XM_006528754
OMIM
CCDS CCDS30454 CCDS57779
HPRD
IMGT
MGI ID MGI:1339656
MGI Symbol Pak3
EMBL AL691499 BX322533 BX530055 BX813331
GenPept
RNA Seq Atlas 18481

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca