Homo sapiens Gene: RICTOR
Summary
InnateDB Gene IDBG-17688.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RICTOR
Gene Name RPTOR independent companion of MTOR, complex 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164327
Encoded Proteins
RPTOR independent companion of MTOR, complex 2
RPTOR independent companion of MTOR, complex 2
RPTOR independent companion of MTOR, complex 2
RPTOR independent companion of MTOR, complex 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
RICTOR reduces TLR4-mediated inflammation by regulating the cellular localization of FOXO1. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Rictor reduces Tlr4-mediated inflammation by regulating the cellular localization of Foxo1.
Entrez Gene
Summary RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:38937919-39074408
Strand Reverse strand
Band p13.1
Transcripts
ENST00000357387 ENSP00000349959
ENST00000296782 ENSP00000296782
ENST00000511516 ENSP00000423019
ENST00000505927
ENST00000503698
ENST00000509567
ENST00000515846
ENST00000510711
ENST00000513566
ENST00000514735 ENSP00000423162
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 112 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 112 [view]
Protein-Protein 110 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0043022 ribosome binding
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009790 embryo development
GO:0030838 positive regulation of actin filament polymerization
GO:0031295 T cell costimulation
GO:0031532 actin cytoskeleton reorganization
GO:0031929 TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0032314 regulation of Rac GTPase activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042325 regulation of phosphorylation
GO:0045087 innate immune response (InnateDB)
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051896 regulation of protein kinase B signaling
GO:0051897 positive regulation of protein kinase B signaling
Cellular Component
GO:0005829 cytosol
GO:0031932 TORC2 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
Oncostatin_M pathway
REACTOME
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
VEGFR2 mediated vascular permeability pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
CD28 co-stimulation pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
CD28 dependent PI3K/Akt signaling pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Costimulation by the CD28 family pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
mTOR signaling pathway pathway
INOH
Insulin receptor signaling pathway
PID BIOCARTA
PID NCI
Class I PI3K signaling events mediated by Akt
CXCR4-mediated signaling events
ErbB1 downstream signaling
mTOR signaling pathway
Integrin-linked kinase signaling
CXCR3-mediated signaling events
Cross-References
SwissProt Q6R327
TrEMBL
UniProt Splice Variant
Entrez Gene 253260
UniGene Hs.407926 Hs.660631 Hs.664078 Hs.670518
RefSeq NM_001285439 NM_152756 NM_001285440 XM_005248278 XM_006714463
HUGO HGNC:28611
OMIM 609022
CCDS CCDS68861 CCDS34148
HPRD 10682
IMGT
EMBL AB082530 AC008964 AC109467 AL834497 AY515854 BC051729 BC137163 BC137164 BC144509 CH471119 CR749280
GenPept AAH51729 AAI37164 AAI37165 AAI44510 AAS79796 BAC02708 CAD39155 CAH18135 EAW55980
RNA Seq Atlas 253260