InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RICTOR

Summary

InnateDB Gene

IDBG-17688.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RICTOR

Gene Name

RPTOR independent companion of MTOR, complex 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000164327

Encoded Proteins

IDBP-17690

RPTOR independent companion of MTOR, complex 2

IDBP-17692

RPTOR independent companion of MTOR, complex 2

IDBP-482447

RPTOR independent companion of MTOR, complex 2

IDBP-483724

RPTOR independent companion of MTOR, complex 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22045807

RICTOR reduces TLR4-mediated inflammation by regulating the cellular localization of FOXO1. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 22045807

[Mus musculus] Rictor reduces Tlr4-mediated inflammation by regulating the cellular localization of Foxo1.

Entrez Gene

Summary

RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:38937919-39074408

Strand

Reverse strand

Band

p13.1

Transcripts

ENST00000357387	ENSP00000349959
ENST00000296782	ENSP00000296782
ENST00000511516	ENSP00000423019
ENST00000505927
ENST00000503698
ENST00000509567
ENST00000515846
ENST00000510711
ENST00000513566
ENST00000514735	ENSP00000423162

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 112 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	112 [view]
Protein-Protein	110 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0043022	ribosome binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009790	embryo development
GO:0030838	positive regulation of actin filament polymerization
GO:0031295	T cell costimulation
GO:0031532	actin cytoskeleton reorganization
GO:0031929	TOR signaling
GO:0032008	positive regulation of TOR signaling
GO:0032314	regulation of Rac GTPase activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042325	regulation of phosphorylation
GO:0045087	innate immune response (InnateDB)
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051896	regulation of protein kinase B signaling
GO:0051897	positive regulation of protein kinase B signaling