InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vps35

Summary

InnateDB Gene

IDBG-177013.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vps35

Gene Name

vacuolar protein sorting 35

Synonyms

AI647796; Mem3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031696

Encoded Proteins

IDBP-177015

vacuolar protein sorting 35

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000069329:
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:85260397-85299513

Strand

Reverse strand

Band

Transcripts

ENSMUST00000034131

ENSMUSP00000034131

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006624	vacuolar protein processing
GO:0015031	protein transport
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005829	cytosol
GO:0016021	integral component of membrane
GO:0030904	retromer complex
GO:0070062	extracellular vesicular exosome