Mus musculus Gene: Fmo5
Summary
InnateDB Gene IDBG-177042.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fmo5
Gene Name flavin containing monooxygenase 5
Synonyms 5033418D19Rik; AI195026
Species Mus musculus
Ensembl Gene ENSMUSG00000028088
Encoded Proteins
flavin containing monooxygenase 5
flavin containing monooxygenase 5
flavin containing monooxygenase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131781:
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:97628804-97655282
Strand Forward strand
Band F2.2
Transcripts
ENSMUST00000029729 ENSMUSP00000029729
ENSMUST00000107050 ENSMUSP00000102665
ENSMUST00000107049 ENSMUSP00000102664
ENSMUST00000133017
ENSMUST00000140283
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004499 N,N-dimethylaniline monooxygenase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Drug metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Drug metabolism pathway
INOH
PID NCI
Cross-References
SwissProt P97872
TrEMBL Q3TRA1 Q3UV28
UniProt Splice Variant
Entrez Gene 14263
UniGene Mm.385180 Mm.475190
RefSeq NM_001161763 NM_001161765 NM_010232 XM_006500995 XM_006500996
OMIM
CCDS CCDS17656
HPRD
IMGT
MGI ID MGI:1310004
MGI Symbol Fmo5
EMBL AK133675 AK137645 AK162951 BC022991 CH466620 U90535
GenPept AAB50013 AAH22991 BAE21778 BAE23445 BAE37129 EDL38939
RNA Seq Atlas 14263