Version 5.4
Mus musculus Gene: Dis3l2
Summary
InnateDB Gene IDBG-177215.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dis3l2
Gene Name DIS3 mitotic control homolog (S. cerevisiae)-like 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000053333
Encoded Proteins
IDBP-177217
DIS3 mitotic control homolog (S. cerevisiae)-like 2
IDBP-627694
DIS3 mitotic control homolog (S. cerevisiae)-like 2
IDBP-787909
DIS3 mitotic control homolog (S. cerevisiae)-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144535:
The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:86703808-87050095
Strand Forward strand
Band C5
Transcripts
ENSMUST00000065694 ENSMUSP00000070506
ENSMUST00000168237 ENSMUSP00000132673
ENSMUST00000188121
ENSMUST00000189044
ENSMUST00000190618 ENSMUSP00000139579
ENSMUST00000186682
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000175 3'-5'-exoribonuclease activity
GO:0003723 RNA binding
GO:0004540 ribonuclease activity
GO:0005515 protein binding
Biological Process
GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic
GO:0007067 mitotic nuclear division
GO:0008285 negative regulation of cell proliferation
GO:0010587 miRNA catabolic process
GO:0019827 stem cell maintenance
GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
GO:0051306 mitotic sister chromatid separation
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1990074 polyuridylation-dependent mRNA catabolic process
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000144535
View Gene Order
ENSBTAG00000011964
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.486643
RefSeq NM_001172157 NM_153530 XM_006529300
OMIM
CCDS CCDS15124 CCDS48304
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca