Version 5.4
Mus musculus Gene: Twf1
Summary
InnateDB Gene IDBG-177408.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Twf1
Gene Name twinfilin, actin-binding protein, homolog 1 (Drosophila)
Synonyms A6; Ptk9; twinfilin
Species Mus musculus
Ensembl Gene ENSMUSG00000022451
Encoded Proteins
IDBP-177410
twinfilin, actin-binding protein, homolog 1 (Drosophila)
IDBP-541128
twinfilin, actin-binding protein, homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151239:
This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:94577951-94589889
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000023087 ENSMUSP00000023087
ENSMUST00000155654
ENSMUST00000127347
ENSMUST00000152590 ENSMUSP00000119302
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Biological Process
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030837 negative regulation of actin filament polymerization
GO:0042989 sequestering of actin monomers
GO:0043538 regulation of actin phosphorylation
GO:0051016 barbed-end actin filament capping
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0015629 actin cytoskeleton
GO:0030016 myofibril
GO:0030175 filopodium
GO:0032587 ruffle membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000151239
View Gene Order
ENSBTAG00000020938
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.490250
RefSeq NM_008971 XM_006508381 XM_006520638 XM_006544229
OMIM
CCDS CCDS27773
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca