Version 5.4
Mus musculus Gene: Hmgcs2
Summary
InnateDB Gene IDBG-177864.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hmgcs2
Gene Name 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
Synonyms 1300002P16; mHS
Species Mus musculus
Ensembl Gene ENSMUSG00000027875
Encoded Proteins
IDBP-177866
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
IDBP-400825
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134240:
The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:98280435-98310738
Strand Forward strand
Band F2.2
Transcripts
ENSMUST00000090746 ENSMUSP00000088249
ENSMUST00000120541 ENSMUSP00000113296
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004421 hydroxymethylglutaryl-CoA synthase activity
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0008152 metabolic process
GO:0008299 isoprenoid biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134240
View Gene Order
ENSBTAG00000003898
Not yet available
Pathways
NETPATH
REACTOME
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_243038
Synthesis of Ketone Bodies pathway
REACT_237455
Ketone body metabolism pathway
REACT_198602
PPARA activates gene expression pathway
KEGG
mmu00280
Valine, leucine and isoleucine degradation pathway
mmu00072
Synthesis and degradation of ketone bodies pathway
mmu03320
PPAR signaling pathway pathway
mmu00900
Terpenoid backbone biosynthesis pathway
mmu00650
Butanoate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1464
Synthesis of Ketone Bodies pathway
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_1861
Ketone body metabolism pathway
REACT_111217
Metabolism pathway
REACT_207951
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_212702
Synthesis of Ketone Bodies pathway
REACT_222008
Ketone body metabolism pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_207237
PPARA activates gene expression pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
KEGG
hsa00900
Terpenoid backbone biosynthesis pathway
hsa00280
Valine, leucine and isoleucine degradation pathway
hsa00650
Butanoate metabolism pathway
hsa00072
Synthesis and degradation of ketone bodies pathway
hsa03320
PPAR signaling pathway pathway
INOH
INOH website
Butanoate metabolism pathway
INOH website
Valine Leucine Isoleucine degradation pathway
PID NCI
myc_represspathway
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt P54869
TrEMBL
UniProt Splice Variant
Entrez Gene 15360
UniGene Mm.289131
RefSeq NM_008256
OMIM
CCDS CCDS17662
HPRD
IMGT
MGI ID MGI:101939
MGI Symbol Hmgcs2
EMBL AK004865 AK004902 BC014714 BC024744 U12790 U12791
GenPept AAA92675 AAA92676 AAH14714 AAH24744 BAB23626 BAB23657
RNA Seq Atlas 15360

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca