InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Obscn

Summary

InnateDB Gene

IDBG-177933.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Obscn

Gene Name

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000061462

Encoded Proteins

IDBP-177777

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

IDBP-177937

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

IDBP-177941

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

IDBP-537690

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

IDBP-532315

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

IDBP-541109

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

IDBP-542604

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 800 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein is one of three giant sacromeric signaling proteins that includes titin and nebulin. It may have a role in the organization of myofibrils during assembly and also may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been described although the full-length nature is not known for all splicing variants. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:58994256-59136402

Strand

Reverse strand

Band

B1.3

Transcripts

ENSMUST00000047441	ENSMUSP00000038264
ENSMUST00000052872	ENSMUSP00000049737
ENSMUST00000020732	ENSMUSP00000020732
ENSMUST00000138587	ENSMUSP00000121092
ENSMUST00000132238	ENSMUSP00000116487
ENSMUST00000127937	ENSMUSP00000120128
ENSMUST00000133040	ENSMUSP00000122181

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction