Mus musculus Gene: Apex2
Summary
InnateDB Gene IDBG-178133.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apex2
Gene Name apurinic/apyrimidinic endonuclease 2
Synonyms ape2; C430040P13Rik;
Species Mus musculus
Ensembl Gene ENSMUSG00000025269
Encoded Proteins
apurinic/apyrimidinic endonuclease 2
apurinic/apyrimidinic endonuclease 2
apurinic/apyrimidinic endonuclease 2
apurinic/apyrimidinic endonuclease 2
apurinic/apyrimidinic endonuclease 2
apurinic/apyrimidinic endonuclease 2
apurinic/apyrimidinic endonuclease 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169188:
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:150519519-150589868
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000026303 ENSMUSP00000026303
ENSMUST00000112727 ENSMUSP00000108347
ENSMUST00000112725 ENSMUSP00000108345
ENSMUST00000112721 ENSMUSP00000108341
ENSMUST00000112720 ENSMUSP00000108340
ENSMUST00000112719 ENSMUSP00000108339
ENSMUST00000152332
ENSMUST00000124521
ENSMUST00000138958
ENSMUST00000140207 ENSMUSP00000122554
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004518 nuclease activity
GO:0008270 zinc ion binding
GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0000738 DNA catabolic process, exonucleolytic
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006310 DNA recombination
GO:0007049 cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Base excision repair pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Base excision repair pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.453804
RefSeq NM_029943
OMIM
CCDS CCDS30463
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas