Version 5.4
Mus musculus Gene: Cldn14
Summary
InnateDB Gene IDBG-178368.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cldn14
Gene Name claudin 14
Synonyms AI851731
Species Mus musculus
Ensembl Gene ENSMUSG00000047109
Encoded Proteins
IDBP-178370
claudin 14
IDBP-626078
claudin 14
IDBP-707509
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the claudin family of tight junction proteins. The encoded protein is an integral membrane protein that may function in maintaining apical membrane polarization in tight junctions located between outer hair cells and supporting cells. Loss of function of this gene is associated with hearing problems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:93919031-94008837
Strand Reverse strand
Band C4
Transcripts
ENSMUST00000050962 ENSMUSP00000062045
ENSMUST00000142083
ENSMUST00000137163
ENSMUST00000169391 ENSMUSP00000126455
ENSMUST00000177648 ENSMUSP00000136156
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0016338 calcium-independent cell-cell adhesion
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159261
View Gene Order
ENSBTAG00000030585
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04530
Tight junction pathway
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu05160
Hepatitis C pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19373
Tight junction interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt Q9Z0S3
TrEMBL A2RSP0
UniProt Splice Variant
Entrez Gene 56173
UniGene Mm.328716
RefSeq NM_019500 NM_001165925 NM_001165926 XM_006523067
OMIM
CCDS CCDS28345
HPRD
IMGT
MGI ID MGI:1860425
MGI Symbol Cldn14
EMBL AF124429 AF314089 AK020255 BC132183 BC138497 CH466602
GenPept AAD17323 AAG60051 AAI32184 AAI38498 BAB32041 EDL03752 EDL03753 EDL03754 EDL03755
RNA Seq Atlas 56173

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca