InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ghrl

Summary

InnateDB Gene

IDBG-178411.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ghrl

Gene Name

ghrelin

Synonyms

2210006E23Rik; Ghr; m46; MTLRP; MTLRPAP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000064177

Encoded Proteins

IDBP-178417

ghrelin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. The hormone ghrelin plays a role in enhancing appetite and has numerous other biological functions that include stimulating the secretion of growth hormone (somatotropin) from the anterior pituitary gland. Obestatin is thought to be a hormone that functions in decreasing appetite. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:113716119-113719880

Strand

Reverse strand

Band

Transcripts

ENSMUST00000064993

ENSMUSP00000069567

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005179	hormone activity
GO:0016608	growth hormone-releasing hormone activity
GO:0030296	protein tyrosine kinase activator activity
GO:0031768	ghrelin receptor binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001696	gastric acid secretion
GO:0001937	negative regulation of endothelial cell proliferation
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008154	actin polymerization or depolymerization
GO:0008343	adult feeding behavior
GO:0009725	response to hormone
GO:0016358	dendrite development
GO:0032024	positive regulation of insulin secretion
GO:0032095	regulation of response to food
GO:0032097	positive regulation of response to food
GO:0032100	positive regulation of appetite
GO:0032691	negative regulation of interleukin-1 beta production
GO:0040013	negative regulation of locomotion
GO:0042127	regulation of cell proliferation
GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep
GO:0042536	negative regulation of tumor necrosis factor biosynthetic process
GO:0043066	negative regulation of apoptotic process
GO:0043627	response to estrogen
GO:0045409	negative regulation of interleukin-6 biosynthetic process
GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep
GO:0046676	negative regulation of insulin secretion
GO:0046697	decidualization
GO:0050728	negative regulation of inflammatory response
GO:0051461	positive regulation of corticotropin secretion
GO:0051464	positive regulation of cortisol secretion
GO:0051965	positive regulation of synapse assembly
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060124	positive regulation of growth hormone secretion
GO:0061098	positive regulation of protein tyrosine kinase activity