Mus musculus Gene: Klk1 | |||||||
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Summary | |||||||
InnateDB Gene | IDBG-178418.6 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | Klk1 | ||||||
Gene Name | kallikrein 1 | ||||||
Synonyms | 0610007D04Rik; Kal; Klk1b6; Klk6; mGk-6 | ||||||
Species | Mus musculus | ||||||
Ensembl Gene | ENSMUSG00000063903 | ||||||
Encoded Proteins |
kallikrein 1
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Protein Structure | |||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||
InnateDB Annotation from Orthologs | |||||||
Summary |
[Homo sapiens] KLK1 is part of the kallikrein-kinin system (KKS) that is involved in cancer and angiogenesis.
[Homo sapiens] KLK1 is involved in the enzymatic cascade known as the contact system in the blood which leads to an inflammatory response.
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Entrez Gene | |||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167748:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||
Type | Protein coding | ||||||
Genomic Location | Chromosome 7:44225437-44229617 | ||||||
Strand | Forward strand | ||||||
Band | B3 | ||||||
Transcripts |
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Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||
Species
Homo sapiens
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Gene ID
Gene Order
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Pathways | |||||||
NETPATH | |||||||
REACTOME |
Activation of Matrix Metalloproteinases pathway
Extracellular matrix organization pathway
Metabolism of proteins pathway
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
Degradation of the extracellular matrix pathway
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KEGG | |||||||
INOH | |||||||
PID NCI | |||||||
Pathway Predictions based on Human Orthology Data | |||||||
NETPATH | |||||||
REACTOME |
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
Metabolism of proteins pathway
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KEGG | |||||||
INOH | |||||||
PID NCI | |||||||
Cross-References | |||||||
SwissProt | P15947 | ||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | 16612 | ||||||
UniGene | |||||||
RefSeq | NM_010639 | ||||||
OMIM | |||||||
CCDS | CCDS21202 | ||||||
HPRD | |||||||
IMGT | |||||||
MGI ID | MGI:102850 | ||||||
MGI Symbol | Klk1 | ||||||
EMBL | AK002278 BC010754 BC027736 BC053697 D10464 M13498 M13499 M13500 | ||||||
GenPept | AAG11389 AAH10754 AAH27736 AAH53697 BAA01257 BAB21982 | ||||||
RNA Seq Atlas | 16612 | ||||||