Version 5.4
Mus musculus Gene: Gna11
Summary
InnateDB Gene IDBG-178777.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gna11
Gene Name guanine nucleotide binding protein, alpha 11
Synonyms Dsk7; E430025L19
Species Mus musculus
Ensembl Gene ENSMUSG00000034781
Encoded Proteins
IDBP-178779
guanine nucleotide binding protein, alpha 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088256:
The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:81528724-81545190
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000043604 ENSMUSP00000043190
ENSMUST00000146984
ENSMUST00000134354
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0046872 metal ion binding
Biological Process
GO:0001501 skeletal system development
GO:0001508 action potential
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007507 heart development
GO:0045634 regulation of melanocyte differentiation
GO:0048066 developmental pigmentation
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
GO:0071467 cellular response to pH
Cellular Component
GO:0005765 lysosomal membrane
GO:0005834 heterotrimeric G-protein complex
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000088256
View Gene Order
ENSBTAG00000012181
Not yet available
Pathways
NETPATH
REACTOME
REACT_258788
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
REACT_223625
GPCR downstream signaling pathway
REACT_208483
Platelet homeostasis pathway
REACT_224553
Hemostasis pathway
REACT_233922
Thromboxane signalling through TP receptor pathway
REACT_254215
Signaling by GPCR pathway
REACT_217323
Integration of energy metabolism pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_247495
Acetylcholine regulates insulin secretion pathway
REACT_188937
Metabolism pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_263148
Regulation of insulin secretion pathway
REACT_250548
Platelet sensitization by LDL pathway
REACT_220322
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_259068
ADP signalling through P2Y purinoceptor 1 pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
REACT_251998
Free fatty acids regulate insulin secretion pathway
REACT_251507
Signal amplification pathway
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04540
Gap junction pathway
mmu04912
GnRH signaling pathway pathway
mmu04730
Long-term depression pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu05146
Amoebiasis pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_23
TSH pathway
REACTOME
REACT_19140
ADP signalling through P2Y purinoceptor 1 pathway
REACT_20647
Thromboxane signalling through TP receptor pathway
REACT_21384
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_18405
Acetylcholine regulates insulin secretion pathway
REACT_19193
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_19375
Free fatty acids regulate insulin secretion pathway
REACT_111217
Metabolism pathway
REACT_20524
Signal amplification pathway
REACT_604
Hemostasis pathway
REACT_216130
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
REACT_214993
Platelet sensitization by LDL pathway
REACT_205036
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_209110
Regulation of insulin secretion pathway
REACT_205369
Signaling by GPCR pathway
REACT_203404
Free fatty acids regulate insulin secretion pathway
REACT_212196
Hemostasis pathway
REACT_217101
Integration of energy metabolism pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_214353
Signal Transduction pathway
REACT_215912
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_222735
Signal amplification pathway
REACT_211557
G-protein mediated events pathway
REACT_209440
Platelet homeostasis pathway
REACT_211545
ADP signalling through P2Y purinoceptor 1 pathway
REACT_209521
G alpha (q) signalling events pathway
REACT_214436
GPCR downstream signaling pathway
REACT_213422
PLC beta mediated events pathway
REACT_210152
Thromboxane signalling through TP receptor pathway
REACT_219139
Metabolism pathway
REACT_219672
Opioid Signalling pathway
REACT_202864
Acetylcholine regulates insulin secretion pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04540
Gap junction pathway
hsa04730
Long-term depression pathway
hsa04020
Calcium signaling pathway pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa05146
Amoebiasis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.260925 Mm.471081
RefSeq NM_010301
OMIM
CCDS CCDS24061
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca