Version 5.4
Mus musculus Gene: Gtf2h4
Summary
InnateDB Gene IDBG-178785.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gtf2h4
Gene Name general transcription factor II H, polypeptide 4
Synonyms AW545633; BTF2 p52; p44; p52; TFIIH
Species Mus musculus
Ensembl Gene ENSMUSG00000001524
Encoded Proteins
IDBP-178787
general transcription factor II H, polypeptide 4
IDBP-537421
general transcription factor II H, polypeptide 4
IDBP-533966
general transcription factor II H, polypeptide 4
IDBP-536842
general transcription factor II H, polypeptide 4
IDBP-537107
general transcription factor II H, polypeptide 4
IDBP-533641
general transcription factor II H, polypeptide 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213780:
Gene Information
Type Protein coding
Genomic Location Chromosome 17:35667730-35673739
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000001565 ENSMUSP00000001565
ENSMUST00000162927
ENSMUST00000160535
ENSMUST00000160734 ENSMUSP00000124335
ENSMUST00000162894
ENSMUST00000160752 ENSMUSP00000124458
ENSMUST00000160039 ENSMUSP00000124683
ENSMUST00000162266 ENSMUSP00000124103
ENSMUST00000159671
ENSMUST00000162604
ENSMUST00000160711
ENSMUST00000159852 ENSMUSP00000124060
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004003 ATP-dependent DNA helicase activity
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0008094 DNA-dependent ATPase activity
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006289 nucleotide-excision repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0000439 core TFIIH complex
GO:0005634 nucleus
GO:0005675 holo TFIIH complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000213780
View Gene Order
ENSBTAG00000046757
Not yet available
Pathways
NETPATH
REACTOME
REACT_230204
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_213655
Transcription-coupled NER (TC-NER) pathway
REACT_245058
RNA Polymerase I Transcription pathway
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_203462
Formation of the Early Elongation Complex pathway
REACT_223654
Formation of transcription-coupled NER (TC-NER) repair complex pathway
REACT_240507
Dual incision reaction in GG-NER pathway
REACT_244380
RNA Polymerase II Transcription Initiation pathway
REACT_255334
RNA Polymerase II Promoter Escape pathway
REACT_238177
Global Genomic NER (GG-NER) pathway
REACT_252106
Formation of incision complex in GG-NER pathway
REACT_257165
RNA Polymerase I Transcription Termination pathway
REACT_235422
Nucleotide Excision Repair pathway
REACT_226759
Formation of RNA Pol II elongation complex pathway
REACT_232708
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_233397
DNA Repair pathway
REACT_226490
RNA Polymerase II Transcription Elongation pathway
REACT_255009
RNA Polymerase II Pre-transcription Events pathway
REACT_258231
mRNA Capping pathway
REACT_233572
Gene Expression pathway
REACT_232235
RNA Polymerase I Promoter Escape pathway
REACT_224562
Dual incision reaction in TC-NER pathway
REACT_240511
RNA Polymerase I Promoter Clearance pathway
REACT_259097
RNA Polymerase I Chain Elongation pathway
REACT_242255
RNA Polymerase II Transcription pathway
REACT_257596
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_235780
RNA Polymerase I Transcription Initiation pathway
KEGG
mmu03022
Basal transcription factors pathway
mmu03420
Nucleotide excision repair pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_1074
RNA Polymerase I Transcription Termination pathway
REACT_2204
RNA Polymerase I Chain Elongation pathway
REACT_1913
RNA Polymerase I Promoter Escape pathway
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_1470
mRNA Capping pathway
REACT_1655
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_1845
Formation of RNA Pol II elongation complex pathway
REACT_846
Formation of the Early Elongation Complex pathway
REACT_833
RNA Polymerase II Transcription Elongation pathway
REACT_2089
RNA Polymerase II Promoter Escape pathway
REACT_1851
RNA Polymerase II Transcription Initiation pathway
REACT_834
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_975
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_22201
Formation of HIV elongation complex in the absence of HIV Tat pathway
REACT_6332
HIV Transcription Initiation pathway
REACT_6253
RNA Polymerase II HIV Promoter Escape pathway
REACT_6319
Formation of the HIV-1 Early Elongation Complex pathway
REACT_6346
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
REACT_6162
Tat-mediated elongation of the HIV-1 transcript pathway
REACT_6237
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_1941
Formation of transcription-coupled NER (TC-NER) repair complex pathway
REACT_2222
Dual incision reaction in TC-NER pathway
REACT_1628
Transcription-coupled NER (TC-NER) pathway
REACT_311
Dual incision reaction in GG-NER pathway
REACT_257
Formation of incision complex in GG-NER pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_2253
Global Genomic NER (GG-NER) pathway
REACT_6274
HIV Transcription Elongation pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_1826
Nucleotide Excision Repair pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_216
DNA Repair pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
KEGG
hsa03022
Basal transcription factors pathway
hsa03420
Nucleotide excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.405927
RefSeq NM_010364 XM_006523668 XM_006523669 XM_006536521 XM_006537254
OMIM
CCDS CCDS28702
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca