Version 5.4
Mus musculus Gene: Mutyh
Summary
InnateDB Gene IDBG-178806.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mutyh
Gene Name mutY homolog (E. coli)
Synonyms 5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb; Mutyhbeta; Mutyhc; Myh
Species Mus musculus
Ensembl Gene ENSMUSG00000028687
Encoded Proteins
IDBP-178808
mutY homolog (E. coli)
IDBP-536875
mutY homolog (E. coli)
IDBP-537074
mutY homolog (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132781:
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:116807723-116819440
Strand Forward strand
Band D1
Transcripts
ENSMUST00000102699 ENSMUSP00000099760
ENSMUST00000130359 ENSMUSP00000122549
ENSMUST00000124857
ENSMUST00000140680
ENSMUST00000155346 ENSMUSP00000122777
ENSMUST00000138056
ENSMUST00000135449
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0019104 DNA N-glycosylase activity
GO:0032407 MutSalpha complex binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000132781
View Gene Order
ENSBTAG00000011242
Not yet available
Pathways
NETPATH
REACTOME
REACT_219627
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
REACT_220827
Displacement of DNA glycosylase by APE1 pathway
REACT_231541
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_245705
Base Excision Repair pathway
REACT_210016
Base-Excision Repair, AP Site Formation pathway
REACT_227394
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_205174
Depurination pathway
REACT_233397
DNA Repair pathway
REACT_219337
Removal of DNA patch containing abasic residue pathway
REACT_205258
Cleavage of the damaged purine pathway
REACT_250836
Resolution of Abasic Sites (AP sites) pathway
REACT_205202
Recognition and association of DNA glycosylase with site containing an affected purine pathway
KEGG
mmu03410
Base excision repair pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1064
Displacement of DNA glycosylase by APE1 pathway
REACT_1357
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
REACT_933
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_2192
Removal of DNA patch containing abasic residue pathway
REACT_1128
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_2176
Recognition and association of DNA glycosylase with site containing an affected purine pathway
REACT_1729
Cleavage of the damaged purine pathway
REACT_1893
Resolution of Abasic Sites (AP sites) pathway
REACT_1104
Base Excision Repair pathway
REACT_804
Base-Excision Repair, AP Site Formation pathway
REACT_626
Depurination pathway
REACT_216
DNA Repair pathway
KEGG
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.180333
RefSeq NM_001159581 NM_133250 XM_006503393
OMIM
CCDS CCDS18518
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca