Version 5.4
Mus musculus Gene: Cd180
Summary
InnateDB Gene IDBG-179053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd180
Gene Name CD180 antigen
Synonyms F630107B15; Ly78; RP105
Species Mus musculus
Ensembl Gene ENSMUSG00000021624
Encoded Proteins
IDBP-179055
CD180 antigen
IDBP-625741
CD180 antigen
IDBP-625742
CD180 antigen
IDBP-625743
CD180 antigen
IDBP-625744
CD180 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19154986
[Homo sapiens] CD180 is an accessory molecule for TLR2, forming part of the receptor complex for innate immune recognition of mycobacterial lipoproteins.
PMID 15852007
[Homo sapiens] CD180 and its helper molecule, LY86, interact directly with the TLR4 signalling complex, inhibiting its ability to bind microbial ligands.
PMID 20133206
[Homo sapiens] CD180 dramatically enhances CpG DNA-induced proliferation/survival by naive B cells but not by memory B cell. This enhancement that is mediated by CD180-induced TLR9 upregulation, leading to Akt activation and sustained NF-kappaB activation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134061:
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:102693558-102739629
Strand Forward strand
Band D1
Transcripts
ENSMUST00000022124 ENSMUSP00000022124
ENSMUST00000171267 ENSMUSP00000129096
ENSMUST00000167144 ENSMUSP00000133015
ENSMUST00000170878 ENSMUSP00000127880
ENSMUST00000172138 ENSMUSP00000131402
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0002322 B cell proliferation involved in immune response
GO:0006954 inflammatory response
GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0045087 innate immune response
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134061
View Gene Order
ENSBTAG00000006360
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_230745
Immune System pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F2Z425
UniProt Splice Variant
Entrez Gene 17079
UniGene Mm.373974
RefSeq NM_008533 XM_006517540
OMIM
CCDS CCDS26741
HPRD
IMGT
MGI ID MGI:1194924
MGI Symbol Cd180
EMBL AC112791 AC239606
GenPept
RNA Seq Atlas 17079

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca