Version 5.4
Mus musculus Gene: Itga6
Summary
InnateDB Gene IDBG-179059.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itga6
Gene Name integrin alpha 6
Synonyms 5033401O05Rik; AI115430; Cd49f; VLA-6
Species Mus musculus
Ensembl Gene ENSMUSG00000027111
Encoded Proteins
IDBP-179063
integrin alpha 6
IDBP-256709
integrin alpha 6
IDBP-534590
integrin alpha 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 4 to bind laminin and to form the main component of hemidesmosomes, which mediate attachment of epithelia to basement membranes. In mouse, deficiency of this gene is associated with absence of hemidesmosomes, severe skin blistering, and early post-natal death. In humans mutations of this gene are associated with epidermolysis bullosa. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:71745616-71858416
Strand Forward strand
Band C2
Transcripts
ENSMUST00000028522 ENSMUSP00000028522
ENSMUST00000112101 ENSMUSP00000107729
ENSMUST00000133124
ENSMUST00000152009
ENSMUST00000155249 ENSMUSP00000118086
ENSMUST00000155596
ENSMUST00000126787
ENSMUST00000139760
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0043236 laminin binding
GO:0046872 metal ion binding
Biological Process
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0010811 positive regulation of cell-substrate adhesion
GO:0016337 single organismal cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0031589 cell-substrate adhesion
GO:0031668 cellular response to extracellular stimulus
GO:0033627 cell adhesion mediated by integrin
GO:0042327 positive regulation of phosphorylation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043065 positive regulation of apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046847 filopodium assembly
GO:0050873 brown fat cell differentiation
GO:0050900 leukocyte migration
GO:0071407 cellular response to organic cyclic compound
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005604 basement membrane
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0016323 basolateral plasma membrane
GO:0030056 hemidesmosome
GO:0030175 filopodium
GO:0034676 alpha6-beta4 integrin complex
GO:0045178 basal part of cell
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000091409
View Gene Order
ENSBTAG00000017266
Not yet available
Pathways
NETPATH
REACTOME
REACT_199045
Collagen formation pathway
REACT_199046
Assembly of collagen fibrils and other multimeric structures pathway
REACT_224553
Hemostasis pathway
REACT_262098
Type I hemidesmosome assembly pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_206066
Extracellular matrix organization pathway
REACT_211508
Basigin interactions pathway
REACT_202342
Laminin interactions pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_241978
Cell junction organization pathway
REACT_223082
Cell-Cell communication pathway
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04512
ECM-receptor interaction pathway
mmu04640
Hematopoietic cell lineage pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu05222
Small cell lung cancer pathway
mmu04510
Focal adhesion pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05200
Pathways in cancer pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
mmu05145
Toxoplasmosis pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
REACTOME
REACT_12560
Basigin interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_20537
Type I hemidesmosome assembly pathway
REACT_111155
Cell-Cell communication pathway
REACT_118779
Extracellular matrix organization pathway
REACT_20676
Cell junction organization pathway
REACT_163942
Syndecan interactions pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_169262
Laminin interactions pathway
REACT_120729
Collagen formation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04640
Hematopoietic cell lineage pathway
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04512
ECM-receptor interaction pathway
hsa05222
Small cell lung cancer pathway
hsa04510
Focal adhesion pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05200
Pathways in cancer pathway
hsa05414
Dilated cardiomyopathy pathway
hsa05145
Toxoplasmosis pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
integrin_cs_pathway
Integrin family cell surface interactions
a6b1_a6b4_integrin_pathway
a6b1 and a6b4 Integrin signaling
myc_represspathway
Validated targets of C-MYC transcriptional repression
integrin4_pathway
Alpha6 beta4 integrin-ligand interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.225096 Mm.445995 Mm.461564 Mm.466325 Mm.470992
RefSeq NM_001277970 NM_008397 XM_006498805 XM_006498806
OMIM
CCDS CCDS16118 CCDS71074
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca