InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cyld

Summary

InnateDB Gene

IDBG-179176.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyld

Gene Name

cylindromatosis (turban tumor syndrome)

Synonyms

2010013M14Rik; 2900009M21Rik; C130039D01Rik; CDMT; CYLD1; EAC; mKIAA0849

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036712

Encoded Proteins

IDBP-179178

cylindromatosis (turban tumor syndrome)

IDBP-179180

cylindromatosis (turban tumor syndrome)

IDBP-261989

cylindromatosis (turban tumor syndrome)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21498625

Cyld is a deubiquitinase that act as a negative regulator of TLR3 induction in response to LPS. (Demonstrated in human)

PMID 21946435

Cyld plays a key role in Type I IFN receptor signalling during vesicular stomatitis virus (VSV) infection. In the absence of Cyld, IFN-beta is ineffective in the induction of antiviral genes.

PMID 22057290

The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.

InnateDB Annotation from Orthologs

Summary

PMID 18636086

[Homo sapiens] CYLD is a negative regulator of DDX58(RIG-I)-mediated antiviral response by removing Lys 63-linked polyubiquitin chains from RIG-I and TBK1.

PMID 18643924

[Homo sapiens] CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia.

PMID 21119682

[Homo sapiens] CYLD is a deubiquitinase that counteracts E3 ligases and therefore play a prominent role in the downregulation of NF-κB signalling and homeostasis.

PMID 21498625

[Homo sapiens] CYLD is a deubiquitinase that act as a negative regulator of TLR3 induction in response to LPS.

PMID 21946435

[Homo sapiens] CYLD plays a key role in Type I IFN receptor signalling during vesicular stomatitis virus (VSV) infection. In the absence of CYLD, IFN-beta is ineffective in the induction of antiviral genes. (Demonstrated in mice)

PMID 22057290

[Homo sapiens] The E3 ligase ITCH and deubiquitinase CYLD act together to regulate TAK1 and inflammation.

PMID 25909817

[Homo sapiens] MIR362 promotes natural killer-cell function by the down-regulation of CYLD.

Entrez Gene

Summary

This gene encodes a protein that is a member of the ubiquitin C-terminal hydrolase subfamily of the deubiquitinating enzyme family. Members of this family catalyze the removal of ubiquitin from a substrate or another ubiquitin molecule and thereby play important roles in regulating signaling pathways, recycling ubiquitin and regulating protein stability. This protein removes ubiquitin from K-63-linked ubiquitin chains from proteins involved in NF-kappaB signaling and thus acts as a negative regulator of this pathway. In humans mutations in this gene have been associated with cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. In mouse deficiency of this gene impairs thymocyte development and increases susceptibility to skin and colon tumors. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:88697028-88751945

Strand

Forward strand

Band

Transcripts

ENSMUST00000043526	ENSMUSP00000039834
ENSMUST00000098519	ENSMUSP00000096119
ENSMUST00000109626	ENSMUSP00000105254

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019901	protein kinase binding
GO:0036459	ubiquitinyl hydrolase activity
GO:0061578	Lys63-specific deubiquitinase activity
GO:0070064	proline-rich region binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007346	regulation of mitotic cell cycle
GO:0016055	Wnt signaling pathway
GO:0016579	protein deubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0045087	innate immune response (InnateDB)
GO:0045581	negative regulation of T cell differentiation
GO:0070266	necroptotic process
GO:0070507	regulation of microtubule cytoskeleton organization
GO:0070536	protein K63-linked deubiquitination
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:1901026	ripoptosome assembly involved in necroptotic process
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
GO:2001242	regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005881	cytoplasmic microtubule
GO:0030496	midbody
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0048471	perinuclear region of cytoplasm