InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Myh14

Summary

InnateDB Gene

IDBG-179395.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myh14

Gene Name

myosin, heavy polypeptide 14

Synonyms

2400004E04Rik; II-C; NHMCII; NMHC II-C

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030739

Encoded Proteins

IDBP-179397

myosin, heavy polypeptide 14

IDBP-265689

myosin, heavy polypeptide 14

IDBP-265691

myosin, heavy polypeptide 14

IDBP-534666

myosin, heavy polypeptide 14

IDBP-789767

myosin, heavy polypeptide 14

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105357:
This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:44605803-44670843

Strand

Reverse strand

Band

Transcripts

ENSMUST00000048102	ENSMUSP00000046059
ENSMUST00000107900	ENSMUSP00000103532
ENSMUST00000107899	ENSMUSP00000103531
ENSMUST00000125870
ENSMUST00000139186
ENSMUST00000125557
ENSMUST00000148487	ENSMUSP00000117143
ENSMUST00000182648	ENSMUSP00000138739

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0030898	actin-dependent ATPase activity
GO:0051015	actin filament binding

Biological Process

GO:0003009	skeletal muscle contraction
GO:0006200	ATP catabolic process
GO:0007519	skeletal muscle tissue development
GO:0007605	sensory perception of sound
GO:0008152	metabolic process
GO:0008360	regulation of cell shape
GO:0014732	skeletal muscle atrophy
GO:0019228	neuronal action potential
GO:0030048	actin filament-based movement
GO:0031032	actomyosin structure organization
GO:0070584	mitochondrion morphogenesis
GO:0071625	vocalization behavior

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016459	myosin complex
GO:0016460	myosin II complex
GO:0030424	axon
GO:0030426	growth cone
GO:0042641	actomyosin
GO:0070062	extracellular vesicular exosome
GO:0097513	myosin II filament