InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Raf1

Summary

InnateDB Gene

IDBG-179428.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Raf1

Gene Name

v-raf-leukemia viral oncogene 1

Synonyms

6430402F14Rik; AA990557; BB129353; c-Raf; Craf1; D830050J10Rik; Raf-1; v-Raf

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000441

Encoded Proteins

IDBP-179430

v-raf-leukemia viral oncogene 1

IDBP-254897

v-raf-leukemia viral oncogene 1

IDBP-540296

v-raf-leukemia viral oncogene 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132155:
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:115618067-115676635

Strand

Reverse strand

Band

Transcripts

ENSMUST00000000451	ENSMUSP00000000451
ENSMUST00000112949	ENSMUSP00000108571
ENSMUST00000130528
ENSMUST00000124553
ENSMUST00000147979	ENSMUSP00000115424
ENSMUST00000127503

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 139 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	47 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	139 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017016	Ras GTPase binding
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0001666	response to hypoxia
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007507	heart development
GO:0008285	negative regulation of cell proliferation
GO:0030154	cell differentiation
GO:0031333	negative regulation of protein complex assembly
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0035019	somatic stem cell maintenance
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process
GO:0045104	intermediate filament cytoskeleton organization
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0071550	death-inducing signaling complex assembly
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0031143	pseudopodium

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000132155

View Gene Order

Pathways

NETPATH

REACTOME

REACT_239142

Innate Immune System pathway

REACT_196640

Stimuli-sensing channels pathway

REACT_245546

GP1b-IX-V activation signalling pathway

REACT_188191

Signaling by ERBB2 pathway

REACT_189085

Disease pathway

REACT_252337

SHC-related events pathway

REACT_242240

RAF/MAP kinase cascade pathway

REACT_224553

Hemostasis pathway

REACT_254215

Signaling by GPCR pathway

REACT_240250

Signaling by Insulin receptor pathway

REACT_261365

Interleukin-2 signaling pathway

REACT_257146

RAF phosphorylates MEK pathway

REACT_227951

Signaling by VEGF pathway

REACT_203664

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_188177

Signaling by FGFR in disease pathway

REACT_188579

Signaling by ERBB4 pathway

REACT_188578

Signaling by SCF-KIT pathway

REACT_188573

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_188574

SHC1 events in ERBB2 signaling pathway

REACT_233584

Cytokine Signaling in Immune system pathway

REACT_245086

VEGFR2 mediated cell proliferation pathway

REACT_198246

CREB phosphorylation through the activation of Ras pathway

REACT_230745

Immune System pathway

REACT_224879

Platelet activation, signaling and aggregation pathway

REACT_218233

Post NMDA receptor activation events pathway

REACT_239466

SHC-mediated signalling pathway

REACT_230639

Downstream signal transduction pathway

REACT_231729

Downstream signaling of activated FGFR pathway

REACT_188580

SHC1 events in ERBB4 signaling pathway

REACT_239722

Signalling to RAS pathway

REACT_260286

SHC1 events in EGFR signaling pathway

REACT_237640

RAF activation pathway

REACT_242976

Signaling by EGFR pathway

REACT_262560

Frs2-mediated activation pathway

REACT_259732

Insulin receptor signalling cascade pathway

REACT_188215

IRS-related events triggered by IGF1R pathway

REACT_188218

IGF1R signaling cascade pathway

REACT_188219

Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway

REACT_237855

Rap1 signalling pathway

REACT_262350

Ion channel transport pathway

REACT_257088

VEGFA-VEGFR2 Pathway pathway

REACT_261444

Axon guidance pathway

REACT_188204

Fc epsilon receptor (FCERI) signaling pathway

REACT_231290

Signalling to ERKs pathway

REACT_261687

Signaling by Interleukins pathway

REACT_253400

Transmembrane transport of small molecules pathway

REACT_248921

Signalling by NGF pathway

REACT_229531

Adaptive Immune System pathway

REACT_263353

Signaling by PDGF pathway

REACT_234357

FRS2-mediated cascade pathway

REACT_259290

Neuronal System pathway

REACT_188576

Developmental Biology pathway

REACT_241824

SOS-mediated signalling pathway

REACT_243154

IRS-related events pathway

REACT_237883

NGF signalling via TRKA from the plasma membrane pathway

REACT_242206

IRS-mediated signalling pathway

REACT_234035

ARMS-mediated activation pathway

REACT_188257

Signal Transduction pathway

REACT_188528

GRB2 events in ERBB2 signaling pathway

REACT_188529

Signaling by Leptin pathway

REACT_250933

Prolonged ERK activation events pathway

REACT_233318

Transmission across Chemical Synapses pathway

REACT_242456

Signaling by FGFR pathway

REACT_245103

GRB2 events in EGFR signaling pathway

REACT_214376

Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway

REACT_188530

FCERI mediated MAPK activation pathway

REACT_247566

MEK activation pathway

REACT_188220

SHC-related events triggered by IGF1R pathway

REACT_188180

Signaling by EGFR in Cancer pathway

REACT_237796

NCAM signaling for neurite out-growth pathway

REACT_252757

Signalling to p38 via RIT and RIN pathway

REACT_188188

DAP12 interactions pathway

REACT_188185

DAP12 signaling pathway

KEGG

mmu05213

Endometrial cancer pathway

mmu05219

Bladder cancer pathway

mmu05211

Renal cell carcinoma pathway

mmu04012

ErbB signaling pathway pathway

mmu04370

VEGF signaling pathway pathway

mmu04910

Insulin signaling pathway pathway

mmu05221

Acute myeloid leukemia pathway

mmu04660

T cell receptor signaling pathway pathway

mmu04916

Melanogenesis pathway

mmu04540

Gap junction pathway

mmu05210

Colorectal cancer pathway

mmu04664

Fc epsilon RI signaling pathway pathway

mmu05218

Melanoma pathway

mmu04650

Natural killer cell mediated cytotoxicity pathway

mmu04912

GnRH signaling pathway pathway

mmu04810

Regulation of actin cytoskeleton pathway

mmu04010

MAPK signaling pathway pathway

mmu04720

Long-term potentiation pathway

mmu05214

Glioma pathway

mmu05215

Prostate cancer pathway

mmu04730

Long-term depression pathway

mmu05220

Chronic myeloid leukemia pathway

mmu05223

Non-small cell lung cancer pathway

mmu04510

Focal adhesion pathway

mmu04662

B cell receptor signaling pathway pathway

mmu05212

Pancreatic cancer pathway

mmu04666

Fc gamma R-mediated phagocytosis pathway

mmu04062

Chemokine signaling pathway pathway

mmu04270

Vascular smooth muscle contraction pathway

mmu04722

Neurotrophin signaling pathway pathway

mmu05200

Pathways in cancer pathway

mmu04914

Progesterone-mediated oocyte maturation pathway

mmu05160

Hepatitis C pathway

INOH