Version 5.4
Mus musculus Gene: Nln
Summary
InnateDB Gene IDBG-179540.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nln
Gene Name neurolysin (metallopeptidase M3 family)
Synonyms 4930472G13Rik; C79345
Species Mus musculus
Ensembl Gene ENSMUSG00000021710
Encoded Proteins
IDBP-262650
neurolysin (metallopeptidase M3 family)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123213:
This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:104023439-104109614
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000109315 ENSMUSP00000104938
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0042277 peptide binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0008150 biological_process
Cellular Component
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000123213
View Gene Order
ENSBTAG00000016903
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04614
Renin-angiotensin system pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04614
Renin-angiotensin system pathway
INOH
PID NCI
Cross-References
SwissProt Q91YP2
TrEMBL Q3TB65
UniProt Splice Variant
Entrez Gene 75805
UniGene Mm.127692
RefSeq NM_029447 XM_006517782 XM_006517783
OMIM
CCDS CCDS36772
HPRD
IMGT
MGI ID MGI:1923055
MGI Symbol Nln
EMBL AK079090 AK146364 AK171432 BC016224 BC025520
GenPept AAH16224 AAH25520 BAC37533 BAE27114 BAE42449
RNA Seq Atlas 75805

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca