InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kif2c

Summary

InnateDB Gene

IDBG-179548.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kif2c

Gene Name

kinesin family member 2C

Synonyms

4930402F02Rik; ESTM5; Knsl6; MCAK; X83316

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028678

Encoded Proteins

IDBP-179550

kinesin family member 2C

IDBP-268766

kinesin family member 2C

IDBP-542942

kinesin family member 2C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142945:
The protein encoded by this gene is a member of kinesin-like protein family. Proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation. [provided by RefSeq, Jul 2008]
This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:117159639-117182639

Strand

Reverse strand

Band

Transcripts

ENSMUST00000065896	ENSMUSP00000064261
ENSMUST00000106436	ENSMUSP00000102044
ENSMUST00000132868
ENSMUST00000142205
ENSMUST00000142138
ENSMUST00000141675
ENSMUST00000148918
ENSMUST00000153953	ENSMUSP00000122655

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0051010	microtubule plus-end binding

Biological Process

GO:0007018	microtubule-based movement
GO:0007019	microtubule depolymerization
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0008152	metabolic process
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity
GO:0051983	regulation of chromosome segregation

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0005881	cytoplasmic microtubule
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0035371	microtubule plus-end