Version 5.4
Mus musculus Gene: Sh3bp4
Summary
InnateDB Gene IDBG-179636.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sh3bp4
Gene Name SH3-domain binding protein 4
Synonyms AI594717; AW227605; BOG25
Species Mus musculus
Ensembl Gene ENSMUSG00000036206
Encoded Proteins
IDBP-179638
SH3-domain binding protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130147:
This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:89070415-89155068
Strand Forward strand
Band D
Transcripts
ENSMUST00000066279 ENSMUSP00000067581
ENSMUST00000123745
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005092 GDP-dissociation inhibitor activity
GO:0005515 protein binding
GO:0017016 Ras GTPase binding
GO:0042802 identical protein binding
Biological Process
GO:0006897 endocytosis
GO:0008285 negative regulation of cell proliferation
GO:0010508 positive regulation of autophagy
GO:0030308 negative regulation of cell growth
GO:0032007 negative regulation of TOR signaling
GO:0034260 negative regulation of GTPase activity
GO:0050790 regulation of catalytic activity
GO:0061462 protein localization to lysosome
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005905 coated pit
GO:0030136 clathrin-coated vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000130147
View Gene Order
ENSBTAG00000013869
Not yet available
Cross-References
SwissProt Q921I6
TrEMBL
UniProt Splice Variant
Entrez Gene 98402
UniGene Mm.170983
RefSeq NM_133816 XM_006529975
OMIM
CCDS CCDS15147
HPRD
IMGT
MGI ID MGI:2138297
MGI Symbol Sh3bp4
EMBL AK028826 AK032634 AK041504 AK043259 BC012284 BC034733
GenPept AAH12284 AAH34733 BAC26140 BAC27961 BAC30966 BAC31506
RNA Seq Atlas 98402

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca