Version 5.4
Mus musculus Gene: Txnrd1
Summary
InnateDB Gene IDBG-179894.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Txnrd1
Gene Name thioredoxin reductase 1
Synonyms TR; TR1; TrxR1
Species Mus musculus
Ensembl Gene ENSMUSG00000020250
Encoded Proteins
IDBP-179896
thioredoxin reductase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the family of pyridine nucleotide-disulfide oxidoreductases. This protein is a flavoenzyme, which uses NADPH for reduction of thioredoxins as well as other protein and nonprotein substrates, and plays a role in protection against oxidative stress. It contains a selenocysteine (Sec) residue, which is essential for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3\' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:82859206-82897724
Strand Forward strand
Band C1
Transcripts
ENSMUST00000020484 ENSMUSP00000020484
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004791 thioredoxin-disulfide reductase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0001707 mesoderm formation
GO:0007369 gastrulation
GO:0008283 cell proliferation
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198431
View Gene Order
ENSBTAG00000013912
Not yet available
Pathways
NETPATH
REACTOME
REACT_238368
Synthesis and interconversion of nucleotide di- and triphosphates pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_188957
Cellular responses to stress pathway
REACT_189141
Detoxification of Reactive Oxygen Species pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_198602
PPARA activates gene expression pathway
REACT_245662
Metabolism of nucleotides pathway
KEGG
mmu00240
Pyrimidine metabolism pathway
mmu00450
Selenocompound metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_21330
Synthesis and interconversion of nucleotide di- and triphosphates pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_120956
Cellular responses to stress pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_172715
Detoxification of Reactive Oxygen Species pathway
REACT_111217
Metabolism pathway
REACT_207951
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_206069
Cellular responses to stress pathway
REACT_204534
Detoxification of Reactive Oxygen Species pathway
REACT_210940
Metabolism of nucleotides pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_207237
PPARA activates gene expression pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_223832
Synthesis and interconversion of nucleotide di- and triphosphates pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00450
Selenocompound metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q9JMH6
TrEMBL Q91Y95 Q91Y98
UniProt Splice Variant
Entrez Gene 50493
UniGene Mm.210155 Mm.471159 Mm.487121
RefSeq NM_001042513 NM_001042514 NM_001042523 NM_015762
OMIM
CCDS CCDS24072
HPRD
IMGT
MGI ID MGI:1354175
MGI Symbol Txnrd1
EMBL AB027565 AF333036 AF394929 AF394930 AF394931 AF394932 AF394933 AF394934 AF394935 AF394936 AF394937 AK011902 AK146125 AK149625 AK168356 BC037643
GenPept AAH37643 AAK01140 AAL27544 AAL27545 BAA86985 BAB27905 BAE26918 BAE28994 BAE40292
RNA Seq Atlas 50493

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca