InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cxcl10

Summary

InnateDB Gene

IDBG-179916.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cxcl10

Gene Name

chemokine (C-X-C motif) ligand 10

Synonyms

C7; CRG-2; gIP-10; Ifi10; INP10; IP-10; IP10; mob-1; Scyb10

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034855

Encoded Proteins

IDBP-179918

chemokine (C-X-C motif) ligand 10

IDBP-400583

chemokine (C-X-C motif) ligand 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21124994

Cxcl10 exert direct antimicrobial effects in vitro against Bacillus anthracis spore and bacilli in a receptor-independent manner and contributes to pulmonary innate immunity.

PMID 21518789

Cxcl10 concentration in blood increases during neonatal polymicrobial sepsis, and the blockade of Cxcl10 not only worsens recruitment and phagocytic function of macrophages, but also the survival of neonatal mice.

PMID 26305961

Nlrp3 deficiency protects mice from the development of type 1 diabetes by suppressing Th1 responses and impairing T-cell migration to pancreatic islets through the down-regulation of chemokine expression (Ccl5, Cxcl10, Irf1) in islets.

InnateDB Annotation from Orthologs

Summary

PMID 21124994

[Homo sapiens] CXCL10 exert direct antimicrobial effects in vitro against Bacillus anthracis spore and bacilli in a receptor-independent manner and contributes to pulmonary innate immunity. (Demonstrated in murine model)

PMID 21518789

[Homo sapiens] CXCL10 concentration in blood increases during neonatal polymicrobial sepsis, and the blockade of CXCL10 not only worsens recruitment and phagocytic function of macrophages, but also the survival of neonatal mice. (Demonstrated in murine model)

PMID 23998932

[Homo sapiens] MIR21 inhibition enhances CCL5 (RANTES) and CXCL10 (IP-10) release in MCF-7 cancer cells and resulted in increased lymphocyte migration . PIAS3 is a target of MIR21 in MCF-7 cells.

PMID 24448099

[Homo sapiens] ISG15 does not directly alter human rhinovirus replication but modulates immune signalling via the viral sensor protein DDX58 to impact production of CXCL10, which has been linked to innate immunity to viruses.

PMID 24448099

[Homo sapiens] Human rhinovirus infection of epithelial cells induces the expression and secretion of ISG15, which modulates immune responses via effects on DDX58, and by regulating CXCL10 production.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169245:
This gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Jul 2008]
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:92346638-92348889

Strand

Reverse strand

Band

Transcripts

ENSMUST00000038816	ENSMUSP00000047646
ENSMUST00000118006	ENSMUSP00000114134
ENSMUST00000138169

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	2 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008009	chemokine activity
GO:0008201	heparin binding
GO:0048248	CXCR3 chemokine receptor binding

Biological Process

GO:0002690	positive regulation of leukocyte chemotaxis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0009306	protein secretion
GO:0009409	response to cold
GO:0009615	response to virus
GO:0010332	response to gamma radiation
GO:0010818	T cell chemotaxis
GO:0010996	response to auditory stimulus
GO:0016525	negative regulation of angiogenesis
GO:0030335	positive regulation of cell migration
GO:0030816	positive regulation of cAMP metabolic process
GO:0032496	response to lipopolysaccharide
GO:0033280	response to vitamin D
GO:0034605	cellular response to heat
GO:0042127	regulation of cell proliferation
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045087	innate immune response (InnateDB)
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051607	defense response to virus
GO:0060326	cell chemotaxis
GO:0070098	chemokine-mediated signaling pathway
GO:0071222	cellular response to lipopolysaccharide
GO:2000406	positive regulation of T cell migration