Version 5.4
Mus musculus Gene: Irx5
Summary
InnateDB Gene IDBG-180170.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Irx5
Gene Name Iroquois related homeobox 5 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000031737
Encoded Proteins
IDBP-180172
Iroquois related homeobox 5 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176842:
This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:92357796-92361456
Strand Forward strand
Band C5
Transcripts
ENSMUST00000034184 ENSMUSP00000034184
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0002027 regulation of heart rate
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007601 visual perception
GO:0008406 gonad development
GO:0010468 regulation of gene expression
GO:0042551 neuron maturation
GO:0048468 cell development
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0050896 response to stimulus
GO:0060040 retinal bipolar neuron differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000176842
View Gene Order
ENSBTAG00000004838
Not yet available
Cross-References
SwissProt Q9JKQ4
TrEMBL Q9ER77
UniProt Splice Variant
Entrez Gene 54352
UniGene Mm.101153
RefSeq NM_018826
OMIM
CCDS CCDS22522
HPRD
IMGT
MGI ID MGI:1859086
MGI Symbol Irx5
EMBL AF165985 AF230074 AJ271053 AK004747 BC051959 BC056994
GenPept AAF42871 AAF63955 AAH51959 AAH56994 BAB23528 CAC10447
RNA Seq Atlas 54352

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca