Mus musculus Gene: Tpm1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-180208.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Tpm1 | ||||||||||||||||||||||
Gene Name | tropomyosin 1, alpha | ||||||||||||||||||||||
Synonyms | AA986836; AI854628; alpha-TM; TM2; Tm3; Tmpa; Tpm-1 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000032366 | ||||||||||||||||||||||
Encoded Proteins |
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
tropomyosin 1, alpha
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140416:
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 9:67022590-67049406 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | C | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Striated Muscle Contraction pathway
Smooth Muscle Contraction pathway
Muscle contraction pathway
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KEGG |
Cardiac muscle contraction pathway
Hypertrophic cardiomyopathy (HCM) pathway
Dilated cardiomyopathy pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Smooth Muscle Contraction pathway
Striated Muscle Contraction pathway
Muscle contraction pathway
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KEGG |
Hypertrophic cardiomyopathy (HCM) pathway
Cardiac muscle contraction pathway
Dilated cardiomyopathy pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.121878 Mm.486857 | ||||||||||||||||||||||
RefSeq | NM_001164248 NM_001164249 NM_001164250 NM_001164251 NM_001164252 NM_001164253 NM_001164254 NM_001164255 NM_001164256 NM_024427 XM_006511044 XM_006511049 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS23311 CCDS52841 CCDS52842 CCDS52843 CCDS52844 CCDS52845 CCDS52846 CCDS52847 CCDS52848 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||