InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Htr2a

Summary

InnateDB Gene

IDBG-180291.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Htr2a

Gene Name

5-hydroxytryptamine (serotonin) receptor 2A

Synonyms

E030013E04; Htr-2; Htr2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034997

Encoded Proteins

IDBP-180293

5-hydroxytryptamine (serotonin) receptor 2A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102468:
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:74640840-74706859

Strand

Forward strand

Band

Transcripts

ENSMUST00000036653

ENSMUSP00000047774

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0032403	protein complex binding
GO:0051378	serotonin binding
GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

Biological Process

GO:0001659	temperature homeostasis
GO:0006874	cellular calcium ion homeostasis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007208	phospholipase C-activating serotonin receptor signaling pathway
GO:0007210	serotonin receptor signaling pathway
GO:0007568	aging
GO:0007613	memory
GO:0008219	cell death
GO:0008284	positive regulation of cell proliferation
GO:0010513	positive regulation of phosphatidylinositol biosynthetic process
GO:0014059	regulation of dopamine secretion
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0014824	artery smooth muscle contraction
GO:0014832	urinary bladder smooth muscle contraction
GO:0019233	sensory perception of pain
GO:0030431	sleep
GO:0033674	positive regulation of kinase activity
GO:0042493	response to drug
GO:0043267	negative regulation of potassium ion transport
GO:0043406	positive regulation of MAP kinase activity
GO:0044380	protein localization to cytoskeleton
GO:0045821	positive regulation of glycolytic process
GO:0045907	positive regulation of vasoconstriction
GO:0046883	regulation of hormone secretion
GO:0048148	behavioral response to cocaine
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050795	regulation of behavior
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft
GO:0070852	cell body fiber