InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lpcat2

Summary

InnateDB Gene

IDBG-180294.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lpcat2

Gene Name

lysophosphatidylcholine acyltransferase 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033192

Encoded Proteins

IDBP-180296

lysophosphatidylcholine acyltransferase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20663880

[Homo sapiens] LPCAT2 is highly expressed in inflammatory cells and is activated by lipopolysaccharide (LPS) treatment through Toll-like receptor 4 (TLR4) and LPCAT2 phosphorylation through LPS-TLR4 signalling may directly depend on MAPK-activated protein kinase 2 (MAPKAPK2).

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087253:
This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:92855350-92919279

Strand

Forward strand

Band

Transcripts

ENSMUST00000046290	ENSMUSP00000049252
ENSMUST00000130471
ENSMUST00000151106

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0005509	calcium ion binding
GO:0016746	transferase activity, transferring acyl groups
GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity
GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity

Biological Process

GO:0006663	platelet activating factor biosynthetic process
GO:0008152	metabolic process
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0061024	membrane organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005795	Golgi stack
GO:0005811	lipid particle
GO:0016021	integral component of membrane