Mus musculus Gene: Gfra1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-180306.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Gfra1 | ||||||||||||||||||||||
Gene Name | glial cell line derived neurotrophic factor family receptor alpha 1 | ||||||||||||||||||||||
Synonyms | AU042498 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000025089 | ||||||||||||||||||||||
Encoded Proteins |
glial cell line derived neurotrophic factor family receptor alpha 1
glial cell line derived neurotrophic factor family receptor alpha 1
glial cell line derived neurotrophic factor family receptor alpha 1
glial cell line derived neurotrophic factor family receptor alpha 1
glial cell line derived neurotrophic factor family receptor alpha 1
glial cell line derived neurotrophic factor family receptor alpha 1
glial cell line derived neurotrophic factor family receptor alpha 1
glial cell line derived neurotrophic factor family receptor alpha 1
glial cell line derived neurotrophic factor family receptor alpha 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151892:
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Feb 2009] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 19:58235604-58455909 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | D2 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
NCAM1 interactions pathway
Axon guidance pathway
Developmental Biology pathway
NCAM signaling for neurite out-growth pathway
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KEGG | |||||||||||||||||||||||
INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
NCAM1 interactions pathway
NCAM signaling for neurite out-growth pathway
Developmental Biology pathway
Axon guidance pathway
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KEGG | |||||||||||||||||||||||
INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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PID NCI |
Signaling events regulated by Ret tyrosine kinase
Posttranslational regulation of adherens junction stability and dissassembly
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.408269 Mm.488676 | ||||||||||||||||||||||
RefSeq | NM_001285457 NM_010279 XM_006526681 XM_006526682 XM_006526683 XM_006526684 XM_006526685 XM_006526686 XM_006526687 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS38028 CCDS70967 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||