Mus musculus Gene: Atf2 | |||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-180520.6 | ||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||
Gene Symbol | Atf2 | ||||||||||||||||||||||||||||||||
Gene Name | activating transcription factor 2 | ||||||||||||||||||||||||||||||||
Synonyms | Atf-2; CRE-BP; Creb2; D130078H02Rik; D18875; mXBP; Tg(Gzma-Klra1)7Wum | ||||||||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000027104 | ||||||||||||||||||||||||||||||||
Encoded Proteins |
activating transcription factor 2
activating transcription factor 2
activating transcription factor 2
activating transcription factor 2
activating transcription factor 2
activating transcription factor 2
activating transcription factor 2
activating transcription factor 2
activating transcription factor 2
activating transcription factor 2
activating transcription factor 2
activating transcription factor 2
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Protein Structure | |||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||
Summary |
[Homo sapiens] SCN5A is a novel pathogen sensor that initiates anti-viral signalling and transcription through ADCY8 and ATF2.
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Entrez Gene | |||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115966:
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell\'s DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014] |
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Gene Information | |||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 2:73816509-73892639 | ||||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||||
Band | C3 | ||||||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 208 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||
REACTOME |
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Chromatin organization pathway
Activation of the AP-1 family of transcription factors pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
MyD88 cascade initiated on plasma membrane pathway
HATs acetylate histones pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Chromatin modifying enzymes pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll-Like Receptors Cascades pathway
MyD88 dependent cascade initiated on endosome pathway
Activated TLR4 signalling pathway
MyD88-independent cascade pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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KEGG |
MAPK signaling pathway pathway
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INOH |
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
BMP2 signaling pathway
TGF-beta signaling pathway
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PID NCI | |||||||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||
NETPATH |
AndrogenReceptor pathway
KitReceptor pathway
TGF_beta_Receptor pathway
TCR pathway
BCR pathway
IL1 pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
RANKL pathway
Leptin pathway
TSH pathway
TSLP pathway
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REACTOME |
Activation of the AP-1 family of transcription factors pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Circadian Clock pathway
HATs acetylate histones pathway
Organelle biogenesis and maintenance pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Mitochondrial biogenesis pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Transcriptional activation of mitochondrial biogenesis pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
Activated TLR4 signalling pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
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KEGG |
MAPK signaling pathway pathway
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INOH |
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
TGF-beta signaling pathway
BMP2 signaling pathway
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PID NCI |
Regulation of retinoblastoma protein
IL12-mediated signaling events
ErbB1 downstream signaling
ATF-2 transcription factor network
AP-1 transcription factor network
RAC1 signaling pathway
CDC42 signaling events
Regulation of nuclear SMAD2/3 signaling
Signaling mediated by p38-alpha and p38-beta
RhoA signaling pathway
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Cross-References | |||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||
TrEMBL | A2AQF0 | ||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||
Entrez Gene | 11909 | ||||||||||||||||||||||||||||||||
UniGene | Mm.209903 Mm.406406 | ||||||||||||||||||||||||||||||||
RefSeq | NM_001025093 NM_001284369 NM_001284372 NM_001284373 NM_009715 XM_006498592 XM_006498593 XM_006498594 XM_006498595 XM_006498596 XM_006498597 XM_006498598 XM_006498599 XM_006543866 | ||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||
CCDS | CCDS16134 CCDS16135 CCDS71076 | ||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||
MGI ID | MGI:109349 | ||||||||||||||||||||||||||||||||
MGI Symbol | Atf2 | ||||||||||||||||||||||||||||||||
EMBL | AL844581 AL845523 | ||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||
RNA Seq Atlas | 102641666 11909 | ||||||||||||||||||||||||||||||||