Version 5.4
Mus musculus Gene: Atf2
Summary
InnateDB Gene IDBG-180520.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atf2
Gene Name activating transcription factor 2
Synonyms Atf-2; CRE-BP; Creb2; D130078H02Rik; D18875; mXBP; Tg(Gzma-Klra1)7Wum
Species Mus musculus
Ensembl Gene ENSMUSG00000027104
Encoded Proteins
IDBP-180522
activating transcription factor 2
IDBP-180524
activating transcription factor 2
IDBP-180526
activating transcription factor 2
IDBP-256901
activating transcription factor 2
IDBP-256903
activating transcription factor 2
IDBP-256905
activating transcription factor 2
IDBP-256907
activating transcription factor 2
IDBP-536314
activating transcription factor 2
IDBP-535865
activating transcription factor 2
IDBP-539888
activating transcription factor 2
IDBP-536009
activating transcription factor 2
IDBP-622922
activating transcription factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25368329
[Homo sapiens] SCN5A is a novel pathogen sensor that initiates anti-viral signalling and transcription through ADCY8 and ATF2.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115966:
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell\'s DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:73816509-73892639
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000055833 ENSMUSP00000058521
ENSMUST00000090802 ENSMUSP00000088311
ENSMUST00000100009 ENSMUSP00000097588
ENSMUST00000112017 ENSMUSP00000107648
ENSMUST00000112016 ENSMUSP00000107647
ENSMUST00000112010 ENSMUSP00000107641
ENSMUST00000112007 ENSMUSP00000107638
ENSMUST00000124737 ENSMUSP00000114828
ENSMUST00000156455
ENSMUST00000143714
ENSMUST00000136958 ENSMUSP00000118357
ENSMUST00000141050
ENSMUST00000154456 ENSMUSP00000118719
ENSMUST00000128531 ENSMUSP00000118560
ENSMUST00000129555
ENSMUST00000138098
ENSMUST00000125159
ENSMUST00000154965
ENSMUST00000173010 ENSMUSP00000133632
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 208 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 29 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 208 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008140 cAMP response element binding protein binding
GO:0019901 protein kinase binding
GO:0035497 cAMP response element binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0003151 outflow tract morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006970 response to osmotic stress
GO:0006974 cellular response to DNA damage stimulus
GO:0016573 histone acetylation
GO:0031573 intra-S DNA damage checkpoint
GO:0032915 positive regulation of transforming growth factor beta2 production
GO:0045444 fat cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060612 adipose tissue development
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane
GO:0035861 site of double-strand break
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115966
View Gene Order
ENSBTAG00000002295
Not yet available
Pathways
NETPATH
REACTOME
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_229712
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_263004
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_218274
Chromatin organization pathway
REACT_204811
Activation of the AP-1 family of transcription factors pathway
REACT_210065
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_245896
MyD88 cascade initiated on plasma membrane pathway
REACT_226917
HATs acetylate histones pathway
REACT_255939
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_262171
MAP kinase activation in TLR cascade pathway
REACT_230745
Immune System pathway
REACT_260773
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_254406
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_249409
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_256727
MyD88 dependent cascade initiated on endosome pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_241786
MyD88-independent cascade pathway
REACT_242921
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_230045
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_261340
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
mmu04010
MAPK signaling pathway pathway
INOH
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
BMP2 signaling pathway
INOH website
TGF-beta signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_13
IL1 pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_17
IL5 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
NetPath_24
TSLP pathway
REACTOME
REACT_21326
Activation of the AP-1 family of transcription factors pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_24941
Circadian Clock pathway
REACT_172610
HATs acetylate histones pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_6900
Immune System pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
il12_2pathway
IL12-mediated signaling events
erbb1_downstream_pathway
ErbB1 downstream signaling
atf2_pathway
ATF-2 transcription factor network
ap1_pathway
AP-1 transcription factor network
rac1_pathway
RAC1 signaling pathway
cdc42_pathway
CDC42 signaling events
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
rhoa_pathway
RhoA signaling pathway
Cross-References
SwissProt
TrEMBL A2AQF0
UniProt Splice Variant
Entrez Gene 11909
UniGene Mm.209903 Mm.406406
RefSeq NM_001025093 NM_001284369 NM_001284372 NM_001284373 NM_009715 XM_006498592 XM_006498593 XM_006498594 XM_006498595 XM_006498596 XM_006498597 XM_006498598 XM_006498599 XM_006543866
OMIM
CCDS CCDS16134 CCDS16135 CCDS71076
HPRD
IMGT
MGI ID MGI:109349
MGI Symbol Atf2
EMBL AL844581 AL845523
GenPept
RNA Seq Atlas 102641666 11909

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca