InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Htr1a

Summary

InnateDB Gene

IDBG-180677.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Htr1a

Gene Name

5-hydroxytryptamine (serotonin) receptor 1A

Synonyms

Gpcr18

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021721

Encoded Proteins

IDBP-180679

5-hydroxytryptamine (serotonin) receptor 1A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178394:
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:105443693-105448133

Strand

Forward strand

Band

Transcripts

ENSMUST00000022235

ENSMUSP00000022235

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0005515	protein binding

Biological Process

GO:0001662	behavioral fear response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007210	serotonin receptor signaling pathway
GO:0008283	cell proliferation
GO:0014062	regulation of serotonin secretion
GO:0035640	exploration behavior
GO:0042053	regulation of dopamine metabolic process
GO:0042310	vasoconstriction
GO:0042428	serotonin metabolic process
GO:0046883	regulation of hormone secretion
GO:0050795	regulation of behavior