Version 5.4
Homo sapiens Gene: TACC1
Summary
InnateDB Gene IDBG-18114.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TACC1
Gene Name transforming, acidic coiled-coil containing protein 1
Synonyms Ga55
Species Homo sapiens
Ensembl Gene ENSG00000147526
Encoded Proteins
IDBP-18120
transforming, acidic coiled-coil containing protein 1
IDBP-18124
transforming, acidic coiled-coil containing protein 1
IDBP-477908
transforming, acidic coiled-coil containing protein 1
IDBP-482888
transforming, acidic coiled-coil containing protein 1
IDBP-813620
transforming, acidic coiled-coil containing protein 1
IDBP-473902
transforming, acidic coiled-coil containing protein 1
IDBP-484502
transforming, acidic coiled-coil containing protein 1
IDBP-476941
transforming, acidic coiled-coil containing protein 1
IDBP-475386
transforming, acidic coiled-coil containing protein 1
IDBP-482845
transforming, acidic coiled-coil containing protein 1
IDBP-484296
transforming, acidic coiled-coil containing protein 1
IDBP-475961
transforming, acidic coiled-coil containing protein 1
IDBP-483915
transforming, acidic coiled-coil containing protein 1
IDBP-478510
transforming, acidic coiled-coil containing protein 1
IDBP-473512
transforming, acidic coiled-coil containing protein 1
IDBP-480590
transforming, acidic coiled-coil containing protein 1
IDBP-474306
transforming, acidic coiled-coil containing protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:38728186-38853028
Strand Forward strand
Band p11.22
Transcripts
ENST00000317827 ENSP00000321703
ENST00000276520 ENSP00000276520
ENST00000519416 ENSP00000428687
ENST00000520615 ENSP00000428450
ENST00000522474
ENST00000520340 ENSP00000473342
ENST00000522983
ENST00000518415 ENSP00000428706
ENST00000521642 ENSP00000428466
ENST00000521050 ENSP00000428949
ENST00000522904 ENSP00000430355
ENST00000522752
ENST00000524354 ENSP00000430562
ENST00000522544
ENST00000523239
ENST00000521528 ENSP00000430819
ENST00000520973 ENSP00000430959
ENST00000521935 ENSP00000428175
ENST00000523834
ENST00000521154
ENST00000524193 ENSP00000429330
ENST00000522955
ENST00000521866 ENSP00000428253
ENST00000518809 ENSP00000430306
ENST00000520611 ENSP00000429418
ENST00000517336
ENST00000519093
ENST00000521568
ENST00000522548
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0007049 cell cycle
GO:0008283 cell proliferation
GO:0021987 cerebral cortex development
GO:0022008 neurogenesis
GO:0022027 interkinetic nuclear migration
GO:0032886 regulation of microtubule-based process
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0015630 microtubule cytoskeleton
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000065954
View Gene Order
ENSBTAG00000004238
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
aurora_a_pathway
Aurora A signaling
aurora_b_pathway
Aurora B signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.618514 Hs.638095 Hs.642259 Hs.733343 Hs.734942
RefSeq NM_001122824 NM_001146216 NM_006283 XM_005273624
HUGO
OMIM
CCDS CCDS47845 CCDS55224 CCDS6109
HPRD 10391
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca