InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sat1

Summary

InnateDB Gene

IDBG-181245.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sat1

Gene Name

spermidine/spermine N1-acetyl transferase 1

Synonyms

AA617398; Sat; SSAT

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025283

Encoded Proteins

IDBP-181247

spermidine/spermine N1-acetyl transferase 1

IDBP-255777

spermidine/spermine N1-acetyl transferase 1

IDBP-787869

spermidine/spermine N1-acetyl transferase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130066:
The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:155213132-155216449

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026318	ENSMUSP00000026318
ENSMUST00000112551	ENSMUSP00000108170
ENSMUST00000152463	ENSMUSP00000138776
ENSMUST00000150046
ENSMUST00000138944
ENSMUST00000134855
ENSMUST00000123337

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004145	diamine N-acetyltransferase activity
GO:0005515	protein binding
GO:0008080	N-acetyltransferase activity
GO:0019809	spermidine binding

Biological Process

GO:0001525	angiogenesis
GO:0006595	polyamine metabolic process
GO:0006598	polyamine catabolic process
GO:0009447	putrescine catabolic process
GO:0032918	spermidine acetylation
GO:0042127	regulation of cell proliferation
GO:0046208	spermine catabolic process