InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mll2

Summary

InnateDB Gene

IDBG-181423.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mll2

Gene Name

myeloid/lymphoid or mixed-lineage leukemia 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000048154

Encoded Proteins

IDBP-181425

myeloid/lymphoid or mixed-lineage leukemia 2

IDBP-744078

IDBP-789159

lysine (K)-specific methyltransferase 2D

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167548:
The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:98831669-98871204

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023741	ENSMUSP00000023741
ENSMUST00000178486	ENSMUSP00000135941
ENSMUST00000184363	ENSMUSP00000139020

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0001555	oocyte growth
GO:0001701	in utero embryonic development
GO:0006342	chromatin silencing
GO:0006351	transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0043627	response to estrogen
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048477	oogenesis
GO:0051568	histone H3-K4 methylation