InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pde4d

Summary

InnateDB Gene

IDBG-181732.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde4d

Gene Name

phosphodiesterase 4D, cAMP specific

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021699

Encoded Proteins

IDBP-181734

phosphodiesterase 4D, cAMP specific

IDBP-181736

phosphodiesterase 4D, cAMP specific

IDBP-400638

phosphodiesterase 4D, cAMP specific

IDBP-400637

phosphodiesterase 4D, cAMP specific

IDBP-400635

phosphodiesterase 4D, cAMP specific

IDBP-400633

phosphodiesterase 4D, cAMP specific

IDBP-400630

phosphodiesterase 4D, cAMP specific

IDBP-400629

phosphodiesterase 4D, cAMP specific

IDBP-400628

phosphodiesterase 4D, cAMP specific

IDBP-540498

phosphodiesterase 4D, cAMP specific

IDBP-536070

phosphodiesterase 4D, cAMP specific

IDBP-535175

phosphodiesterase 4D, cAMP specific

IDBP-714677

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113448:
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
This gene encodes one of four mammalian counterparts to the fruit fly \'dunce\' gene. The encoded protein has 3\',5\'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:108449948-109953461

Strand

Forward strand

Band

D2.1

Transcripts

ENSMUST00000079975	ENSMUSP00000078891
ENSMUST00000074103	ENSMUSP00000073742
ENSMUST00000122041	ENSMUSP00000113488
ENSMUST00000120671	ENSMUSP00000112991
ENSMUST00000119507	ENSMUSP00000114089
ENSMUST00000120664	ENSMUSP00000113024
ENSMUST00000119672	ENSMUSP00000113567
ENSMUST00000117879	ENSMUSP00000112774
ENSMUST00000117420	ENSMUSP00000113610
ENSMUST00000133929
ENSMUST00000151111
ENSMUST00000129374
ENSMUST00000138938
ENSMUST00000153234	ENSMUSP00000121592
ENSMUST00000135275	ENSMUSP00000119583
ENSMUST00000134973
ENSMUST00000152630
ENSMUST00000151429
ENSMUST00000155459	ENSMUSP00000114945
ENSMUST00000177907	ENSMUSP00000136485

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004112	cyclic-nucleotide phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0017124	SH3 domain binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0030552	cAMP binding
GO:0031625	ubiquitin protein ligase binding
GO:0031698	beta-2 adrenergic receptor binding
GO:0044325	ion channel binding
GO:0046872	metal ion binding
GO:0051117	ATPase binding
GO:0097110	scaffold protein binding

Biological Process

GO:0002027	regulation of heart rate
GO:0006198	cAMP catabolic process
GO:0006939	smooth muscle contraction
GO:0007165	signal transduction
GO:0007568	aging
GO:0007613	memory
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0010469	regulation of receptor activity
GO:0010738	regulation of protein kinase A signaling
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014911	positive regulation of smooth muscle cell migration
GO:0030324	lung development
GO:0030593	neutrophil chemotaxis
GO:0032729	positive regulation of interferon-gamma production
GO:0032743	positive regulation of interleukin-2 production
GO:0032754	positive regulation of interleukin-5 production
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0035264	multicellular organism growth
GO:0043623	cellular protein complex assembly
GO:0045822	negative regulation of heart contraction
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050852	T cell receptor signaling pathway
GO:0050900	leukocyte migration
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0061028	establishment of endothelial barrier
GO:0071222	cellular response to lipopolysaccharide
GO:0071320	cellular response to cAMP
GO:0071872	cellular response to epinephrine stimulus
GO:0071875	adrenergic receptor signaling pathway
GO:0086004	regulation of cardiac muscle cell contraction
GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1901898	negative regulation of relaxation of cardiac muscle

Cellular Component

GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0030016	myofibril
GO:0034704	calcium channel complex