Mus musculus Gene: Pde4d
Summary
InnateDB Gene IDBG-181732.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pde4d
Gene Name phosphodiesterase 4D, cAMP specific
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000021699
Encoded Proteins
phosphodiesterase 4D, cAMP specific
phosphodiesterase 4D, cAMP specific
phosphodiesterase 4D, cAMP specific
phosphodiesterase 4D, cAMP specific
phosphodiesterase 4D, cAMP specific
phosphodiesterase 4D, cAMP specific
phosphodiesterase 4D, cAMP specific
phosphodiesterase 4D, cAMP specific
phosphodiesterase 4D, cAMP specific
phosphodiesterase 4D, cAMP specific
phosphodiesterase 4D, cAMP specific
phosphodiesterase 4D, cAMP specific
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113448:
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
This gene encodes one of four mammalian counterparts to the fruit fly \'dunce\' gene. The encoded protein has 3\',5\'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:108449948-109953461
Strand Forward strand
Band D2.1
Transcripts
ENSMUST00000079975 ENSMUSP00000078891
ENSMUST00000074103 ENSMUSP00000073742
ENSMUST00000122041 ENSMUSP00000113488
ENSMUST00000120671 ENSMUSP00000112991
ENSMUST00000119507 ENSMUSP00000114089
ENSMUST00000120664 ENSMUSP00000113024
ENSMUST00000119672 ENSMUSP00000113567
ENSMUST00000117879 ENSMUSP00000112774
ENSMUST00000117420 ENSMUSP00000113610
ENSMUST00000133929
ENSMUST00000151111
ENSMUST00000129374
ENSMUST00000138938
ENSMUST00000153234 ENSMUSP00000121592
ENSMUST00000135275 ENSMUSP00000119583
ENSMUST00000134973
ENSMUST00000152630
ENSMUST00000151429
ENSMUST00000155459 ENSMUSP00000114945
ENSMUST00000177907 ENSMUSP00000136485
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004112 cyclic-nucleotide phosphodiesterase activity
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030552 cAMP binding
GO:0031625 ubiquitin protein ligase binding
GO:0031698 beta-2 adrenergic receptor binding
GO:0044325 ion channel binding
GO:0046872 metal ion binding
GO:0051117 ATPase binding
GO:0097110 scaffold protein binding
Biological Process
GO:0002027 regulation of heart rate
GO:0006198 cAMP catabolic process
GO:0006939 smooth muscle contraction
GO:0007165 signal transduction
GO:0007568 aging
GO:0007613 memory
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0010469 regulation of receptor activity
GO:0010738 regulation of protein kinase A signaling
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014911 positive regulation of smooth muscle cell migration
GO:0030324 lung development
GO:0030593 neutrophil chemotaxis
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0032754 positive regulation of interleukin-5 production
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035264 multicellular organism growth
GO:0043623 cellular protein complex assembly
GO:0045822 negative regulation of heart contraction
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0061028 establishment of endothelial barrier
GO:0071222 cellular response to lipopolysaccharide
GO:0071320 cellular response to cAMP
GO:0071872 cellular response to epinephrine stimulus
GO:0071875 adrenergic receptor signaling pathway
GO:0086004 regulation of cardiac muscle cell contraction
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1901898 negative regulation of relaxation of cardiac muscle
Cellular Component
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0030016 myofibril
GO:0034704 calcium channel complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
GPCR downstream signaling pathway
Signaling by GPCR pathway
DARPP-32 events pathway
Opioid Signalling pathway
Signal Transduction pathway
KEGG
Purine metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TSH pathway
REACTOME
G alpha (s) signalling events pathway
Signaling by GPCR pathway
Opioid Signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
DARPP-32 events pathway
KEGG
Purine metabolism pathway
INOH
Purine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.408046 Mm.435323 Mm.436750 Mm.485166
RefSeq NM_011056
OMIM
CCDS CCDS49359
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas