Version 5.4
Homo sapiens Gene: ATP2B2
Summary
InnateDB Gene IDBG-18189.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP2B2
Gene Name ATPase, Ca++ transporting, plasma membrane 2
Synonyms PMCA2; PMCA2a; PMCA2i
Species Homo sapiens
Ensembl Gene ENSG00000157087
Encoded Proteins
IDBP-18191
ATPase, Ca++ transporting, plasma membrane 2
IDBP-18193
ATPase, Ca++ transporting, plasma membrane 2
IDBP-18197
ATPase, Ca++ transporting, plasma membrane 2
IDBP-236121
ATPase, Ca++ transporting, plasma membrane 2
IDBP-363202
ATPase, Ca++ transporting, plasma membrane 2
IDBP-477972
ATPase, Ca++ transporting, plasma membrane 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:10324023-10708031
Strand Reverse strand
Band p25.3
Transcripts
ENST00000383800 ENSP00000373311
ENST00000360273 ENSP00000353414
ENST00000352432 ENSP00000324172
ENST00000397077 ENSP00000380267
ENST00000452124 ENSP00000414854
ENST00000460129 ENSP00000424494
ENST00000467702
ENST00000468426
ENST00000480680
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005388 calcium-transporting ATPase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0019829 cation-transporting ATPase activity
GO:0030165 PDZ domain binding
GO:0030899 calcium-dependent ATPase activity
GO:0046872 metal ion binding
Biological Process
GO:0000902 cell morphogenesis
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006996 organelle organization
GO:0007595 lactation
GO:0007596 blood coagulation
GO:0007605 sensory perception of sound
GO:0007626 locomotory behavior
GO:0008152 metabolic process
GO:0008361 regulation of cell size
GO:0021549 cerebellum development
GO:0021692 cerebellar Purkinje cell layer morphogenesis
GO:0021702 cerebellar Purkinje cell differentiation
GO:0021707 cerebellar granule cell differentiation
GO:0030182 neuron differentiation
GO:0034220 ion transmembrane transport
GO:0040011 locomotion
GO:0042428 serotonin metabolic process
GO:0042472 inner ear morphogenesis
GO:0045299 otolith mineralization
GO:0046068 cGMP metabolic process
GO:0048167 regulation of synaptic plasticity
GO:0048839 inner ear development
GO:0050808 synapse organization
GO:0050885 neuromuscular process controlling balance
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0051480 cytosolic calcium ion homeostasis
GO:0051928 positive regulation of calcium ion transport
GO:0055085 transmembrane transport
GO:0060088 auditory receptor cell stereocilium organization
GO:0060113 inner ear receptor cell differentiation
GO:0070588 calcium ion transmembrane transport
GO:0090102 cochlea development
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000030302
View Gene Order
Pathways
NETPATH
REACTOME
REACT_23765
Reduction of cytosolic Ca++ levels pathway
REACT_23876
Platelet homeostasis pathway
REACT_25149
Ion transport by P-type ATPases pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_23905
Platelet calcium homeostasis pathway
REACT_25300
Ion channel transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa04020
Calcium signaling pathway pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.268942
RefSeq NM_001001331 NM_001683 XM_005265179 XM_006713175 XM_006713176 XM_006713181
HUGO
OMIM
CCDS CCDS2601 CCDS33701
HPRD 00160
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca