InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grk5

Summary

InnateDB Gene

IDBG-181926.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grk5

Gene Name

G protein-coupled receptor kinase 5

Synonyms

Gprk5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003228

Encoded Proteins

IDBP-181928

G protein-coupled receptor kinase 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20945396

[Homo sapiens] GRK5 is a serine/threonine kinase has a role in the regulation of G-protein coupled receptor (GPCR) signalling and is also an important regulator of signalling pathways stimulated by non-GPCRs. GRK5 also is a positive regulator of TLR4-induced I-kappa-B-alpha-NFkappaB pathway as well as a key modulator of lipopolysaccharide-induced inflammatory response.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198873:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:60889749-61092553

Strand

Forward strand

Band

Transcripts

ENSMUST00000003313

ENSMUSP00000003313

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 162 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	162 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004703	G-protein coupled receptor kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008289	lipid binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007217	tachykinin receptor signaling pathway
GO:0016055	Wnt signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0046777	protein autophosphorylation