Version 5.4
Mus musculus Gene: Cacna1c
Summary
InnateDB Gene IDBG-182003.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cacna1c
Gene Name calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms Cav1.2; Cchl1a1; D930026N18Rik; MBC; MELC-CC
Species Mus musculus
Ensembl Gene ENSMUSG00000051331
Encoded Proteins
IDBP-182005
calcium channel, voltage-dependent, L type, alpha 1C subunit
IDBP-182007
calcium channel, voltage-dependent, L type, alpha 1C subunit
IDBP-255162
calcium channel, voltage-dependent, L type, alpha 1C subunit
IDBP-255164
calcium channel, voltage-dependent, L type, alpha 1C subunit
IDBP-255166
calcium channel, voltage-dependent, L type, alpha 1C subunit
IDBP-790569
calcium channel, voltage-dependent, L type, alpha 1C subunit
IDBP-790570
calcium channel, voltage-dependent, L type, alpha 1C subunit
IDBP-790571
calcium channel, voltage-dependent, L type, alpha 1C subunit
IDBP-790572
calcium channel, voltage-dependent, L type, alpha 1C subunit
IDBP-790573
calcium channel, voltage-dependent, L type, alpha 1C subunit
IDBP-790574
calcium channel, voltage-dependent, L type, alpha 1C subunit
IDBP-790575
calcium channel, voltage-dependent, L type, alpha 1C subunit
IDBP-790576
calcium channel, voltage-dependent, L type, alpha 1C subunit
IDBP-790577
calcium channel, voltage-dependent, L type, alpha 1C subunit
IDBP-790578
calcium channel, voltage-dependent, L type, alpha 1C subunit
IDBP-790579
calcium channel, voltage-dependent, L type, alpha 1C subunit
IDBP-790580
calcium channel, voltage-dependent, L type, alpha 1C subunit
IDBP-790581
calcium channel, voltage-dependent, L type, alpha 1C subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151067:
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:118587240-119196418
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000078320 ENSMUSP00000077433
ENSMUST00000075591 ENSMUSP00000075021
ENSMUST00000112825 ENSMUSP00000108444
ENSMUST00000112793 ENSMUSP00000108413
ENSMUST00000112790 ENSMUSP00000108410
ENSMUST00000186889 ENSMUSP00000140056
ENSMUST00000191196
ENSMUST00000188181
ENSMUST00000187940 ENSMUSP00000141033
ENSMUST00000188522 ENSMUSP00000140920
ENSMUST00000187474 ENSMUSP00000140961
ENSMUST00000188078 ENSMUSP00000140415
ENSMUST00000189389 ENSMUSP00000139855
ENSMUST00000189520 ENSMUSP00000140220
ENSMUST00000187317 ENSMUSP00000140693
ENSMUST00000185345 ENSMUSP00000140833
ENSMUST00000188865 ENSMUSP00000139981
ENSMUST00000187386 ENSMUSP00000140341
ENSMUST00000188106 ENSMUSP00000140886
ENSMUST00000190285 ENSMUSP00000141015
ENSMUST00000187849
ENSMUST00000189930
ENSMUST00000189057
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008331 high voltage-gated calcium channel activity
GO:0019899 enzyme binding
GO:0046872 metal ion binding
GO:0051393 alpha-actinin binding
Biological Process
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006939 smooth muscle contraction
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007268 synaptic transmission
GO:0007628 adult walking behavior
GO:0008217 regulation of blood pressure
GO:0008542 visual learning
GO:0017156 calcium ion-dependent exocytosis
GO:0019229 regulation of vasoconstriction
GO:0030073 insulin secretion
GO:0030252 growth hormone secretion
GO:0034765 regulation of ion transmembrane transport
GO:0042593 glucose homeostasis
GO:0046620 regulation of organ growth
GO:0055085 transmembrane transport
GO:0060083 smooth muscle contraction involved in micturition
GO:0070509 calcium ion import
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0002095 caveolar macromolecular signaling complex
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0043025 neuronal cell body
GO:0043198 dendritic shaft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000151067
View Gene Order
ENSBTAG00000010660
Not yet available
Pathways
NETPATH
REACTOME
REACT_217323
Integration of energy metabolism pathway
REACT_236183
NCAM1 interactions pathway
REACT_188937
Metabolism pathway
REACT_263148
Regulation of insulin secretion pathway
REACT_261444
Axon guidance pathway
REACT_188576
Developmental Biology pathway
REACT_237796
NCAM signaling for neurite out-growth pathway
KEGG
mmu04930
Type II diabetes mellitus pathway
mmu04020
Calcium signaling pathway pathway
mmu05010
Alzheimer's disease pathway
mmu04912
GnRH signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
mmu04720
Long-term potentiation pathway
mmu04260
Cardiac muscle contraction pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
INOH
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18339
Adrenaline,noradrenaline inhibits insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_18312
NCAM1 interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
REACT_111217
Metabolism pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
hsa04720
Long-term potentiation pathway
hsa05010
Alzheimer's disease pathway
hsa04930
Type II diabetes mellitus pathway
hsa04020
Calcium signaling pathway pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001159533 NM_001159534 NM_001159535 NM_001255997 NM_001255998 NM_001255999 NM_001256000 NM_001256001 NM_001256002 NM_001290335 NM_009781 XM_006505434 XM_006505435 XM_006505436 XM_006505437 XM_006505438 XM_006505444
OMIM
CCDS CCDS71821
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca