InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hnrnpd

Summary

InnateDB Gene

IDBG-182638.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hnrnpd

Gene Name

heterogeneous nuclear ribonucleoprotein D

Synonyms

Auf1; Hnrpd

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000568

Encoded Proteins

IDBP-182640

heterogeneous nuclear ribonucleoprotein D

IDBP-182642

heterogeneous nuclear ribonucleoprotein D

IDBP-254928

heterogeneous nuclear ribonucleoprotein D

IDBP-625945

heterogeneous nuclear ribonucleoprotein D

IDBP-625949

heterogeneous nuclear ribonucleoprotein D

IDBP-625950

heterogeneous nuclear ribonucleoprotein D

IDBP-625951

heterogeneous nuclear ribonucleoprotein D

IDBP-625952

heterogeneous nuclear ribonucleoprotein D

IDBP-625953

heterogeneous nuclear ribonucleoprotein D

IDBP-625955

heterogeneous nuclear ribonucleoprotein D

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138668:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:99958426-99978938

Strand

Reverse strand

Band

Transcripts

ENSMUST00000072750	ENSMUSP00000072533
ENSMUST00000019128	ENSMUSP00000019128
ENSMUST00000112939	ENSMUSP00000108561
ENSMUST00000172361	ENSMUSP00000132735
ENSMUST00000171106	ENSMUSP00000131262
ENSMUST00000171640	ENSMUSP00000127833
ENSMUST00000164833	ENSMUSP00000131785
ENSMUST00000168396	ENSMUSP00000131859
ENSMUST00000167035	ENSMUSP00000129950
ENSMUST00000170654
ENSMUST00000171786	ENSMUSP00000125984
ENSMUST00000170912

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 109 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	109 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0042162	telomeric DNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0042752	regulation of circadian rhythm
GO:0043488	regulation of mRNA stability
GO:0045727	positive regulation of translation
GO:0097167	circadian regulation of translation