Version 5.4
Mus musculus Gene: Ppih
Summary
InnateDB Gene IDBG-182988.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppih
Gene Name peptidyl prolyl isomerase H
Synonyms 1100001J08Rik; 2010111B15Rik; 4833408F11Rik; AI464484; CYP-20; CYPH; D4Wsu43e
Species Mus musculus
Ensembl Gene ENSMUSG00000060288
Encoded Proteins
IDBP-182990
peptidyl prolyl isomerase H
IDBP-268989
peptidyl prolyl isomerase H
IDBP-268991
peptidyl prolyl isomerase H
IDBP-268993
peptidyl prolyl isomerase H
IDBP-268995
peptidyl prolyl isomerase H
IDBP-535293
peptidyl prolyl isomerase H
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171960:
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:119300010-119320546
Strand Reverse strand
Band D2.1
Transcripts
ENSMUST00000056458 ENSMUSP00000051221
ENSMUST00000106321 ENSMUSP00000101928
ENSMUST00000106319 ENSMUSP00000101926
ENSMUST00000106318 ENSMUSP00000101925
ENSMUST00000106317 ENSMUSP00000101924
ENSMUST00000147077 ENSMUSP00000118407
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006397 mRNA processing
GO:0006457 protein folding
GO:0008380 RNA splicing
GO:0045070 positive regulation of viral genome replication
Cellular Component
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0016607 nuclear speck
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071001 U4/U6 snRNP
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171960
View Gene Order
ENSBTAG00000004590
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03040
Spliceosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.371613 Mm.380651 Mm.395822 Mm.489485
RefSeq NM_001110129 NM_001110130 NM_028677 XM_006523363 XM_006543353
OMIM
CCDS CCDS18580 CCDS51288
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca