Version 5.4
Mus musculus Gene: Olfm4
Summary
InnateDB Gene IDBG-183156.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Olfm4
Gene Name olfactomedin 4
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000022026
Encoded Proteins
IDBP-183158
olfactomedin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22844115
Olfm4 is a negative regulator of neutrophil bactericidal activity by restricting cathepsin C-mediated protease activities.
InnateDB Annotation from Orthologs
Summary
PMID 20534456
[Homo sapiens] OLFM4 exerts considerable influence on the host defence against H. pylori infection acting through NOD1 and NOD2 mediated NF-kappaB activation and subsequent cytokines and chemokines production, which in turn inhibit host immune response and contribute to persistence of H. pylori colonization.
PMID 22844115
[Homo sapiens] OLFM4 is a negative regulator of neutrophil bactericidal activity by restricting cathepsin C-mediated protease activities. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102837:
This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:80000302-80021930
Strand Forward strand
Band D3
Transcripts
ENSMUST00000088735 ENSMUSP00000086112
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0045296 cadherin binding
Biological Process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0050777 negative regulation of immune response
GO:0051260 protein homooligomerization
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0042581 specific granule
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102837
View Gene Order
ENSBTAG00000022779
Not yet available
Cross-References
SwissProt
TrEMBL D3YYD0
UniProt Splice Variant
Entrez Gene 380924
UniGene
RefSeq NM_001030294
OMIM
CCDS CCDS36989
HPRD
IMGT
MGI ID MGI:2685142
MGI Symbol Olfm4
EMBL AC146609
GenPept
RNA Seq Atlas 380924

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca