Mus musculus Gene: Tcf12
Summary
InnateDB Gene IDBG-183195.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tcf12
Gene Name transcription factor 12
Synonyms A130037E08Rik; ALF1; bHLHb20; HEB; HEBAlt; HTF-4; HTF4; ME1; REB;
Species Mus musculus
Ensembl Gene ENSMUSG00000032228
Encoded Proteins
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140262:
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:71842688-72111871
Strand Reverse strand
Band D
Transcripts
ENSMUST00000034755 ENSMUSP00000034755
ENSMUST00000183404 ENSMUSP00000139365
ENSMUST00000184770
ENSMUST00000183918 ENSMUSP00000138978
ENSMUST00000184867 ENSMUSP00000139233
ENSMUST00000185117 ENSMUSP00000138925
ENSMUST00000184783 ENSMUSP00000139364
ENSMUST00000184448 ENSMUSP00000139334
ENSMUST00000184523 ENSMUSP00000138832
ENSMUST00000183992 ENSMUSP00000139084
ENSMUST00000183784
ENSMUST00000184378 ENSMUSP00000139268
ENSMUST00000184072 ENSMUSP00000139284
ENSMUST00000184416 ENSMUSP00000139008
ENSMUST00000183647 ENSMUSP00000139139
ENSMUST00000183492 ENSMUSP00000138939
ENSMUST00000184107 ENSMUSP00000139248
ENSMUST00000184029 ENSMUSP00000138807
ENSMUST00000183594 ENSMUSP00000138952
ENSMUST00000184196
ENSMUST00000184806
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 20 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043425 bHLH transcription factor binding
GO:0044212 transcription regulatory region DNA binding
GO:0046332 SMAD binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0010628 positive regulation of gene expression
GO:0045666 positive regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
ID pathway
REACTOME
Developmental Biology pathway
CDO in myogenesis pathway
Myogenesis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q61286
TrEMBL
UniProt Splice Variant
Entrez Gene 21406
UniGene
RefSeq NM_001253863 NM_011544 NM_001253862 NM_001253865 NM_001253864 XM_006510999 XM_006510998 XM_006510997 XM_006511001 XM_006510996 XM_006510995 XM_006510994
OMIM
CCDS CCDS23329 CCDS72272 CCDS72271
HPRD
IMGT
MGI ID MGI:101877
MGI Symbol Tcf12
EMBL AC093483 AC157575 AC159001 M97635 M97636 X64840
GenPept CAA46052
RNA Seq Atlas 21406