Version 5.4
Mus musculus Gene: Tcf12
Summary
InnateDB Gene IDBG-183195.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tcf12
Gene Name transcription factor 12
Synonyms A130037E08Rik; ALF1; bHLHb20; HEB; HEBAlt; HTF-4; HTF4; ME1; REB
Species Mus musculus
Ensembl Gene ENSMUSG00000032228
Encoded Proteins
IDBP-183197
transcription factor 12
IDBP-789112
transcription factor 12
IDBP-789115
transcription factor 12
IDBP-789116
transcription factor 12
IDBP-789117
transcription factor 12
IDBP-789118
transcription factor 12
IDBP-789119
transcription factor 12
IDBP-789120
transcription factor 12
IDBP-789122
transcription factor 12
IDBP-789123
transcription factor 12
IDBP-789126
transcription factor 12
IDBP-789127
transcription factor 12
IDBP-789129
transcription factor 12
IDBP-789131
transcription factor 12
IDBP-789135
transcription factor 12
IDBP-789138
transcription factor 12
IDBP-789140
transcription factor 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140262:
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:71842688-72111871
Strand Reverse strand
Band D
Transcripts
ENSMUST00000034755 ENSMUSP00000034755
ENSMUST00000183404 ENSMUSP00000139365
ENSMUST00000184770
ENSMUST00000183918 ENSMUSP00000138978
ENSMUST00000184867 ENSMUSP00000139233
ENSMUST00000185117 ENSMUSP00000138925
ENSMUST00000184783 ENSMUSP00000139364
ENSMUST00000184448 ENSMUSP00000139334
ENSMUST00000184523 ENSMUSP00000138832
ENSMUST00000183992 ENSMUSP00000139084
ENSMUST00000183784
ENSMUST00000184378 ENSMUSP00000139268
ENSMUST00000184072 ENSMUSP00000139284
ENSMUST00000184416 ENSMUSP00000139008
ENSMUST00000183647 ENSMUSP00000139139
ENSMUST00000183492 ENSMUSP00000138939
ENSMUST00000184107 ENSMUSP00000139248
ENSMUST00000184029 ENSMUSP00000138807
ENSMUST00000183594 ENSMUSP00000138952
ENSMUST00000184196
ENSMUST00000184806
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 20 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043425 bHLH transcription factor binding
GO:0044212 transcription regulatory region DNA binding
GO:0046332 SMAD binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0010628 positive regulation of gene expression
GO:0045666 positive regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140262
View Gene Order
ENSBTAG00000002586
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_5
ID pathway
REACTOME
REACT_21402
CDO in myogenesis pathway
REACT_111045
Developmental Biology pathway
REACT_21303
Myogenesis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL V9GXP0
UniProt Splice Variant
Entrez Gene 21406
UniGene
RefSeq NM_001253862 NM_001253863 NM_001253864 NM_001253865 NM_011544 XM_006510994 XM_006510995 XM_006510996 XM_006510997 XM_006510998 XM_006510999 XM_006511001
OMIM
CCDS CCDS23329 CCDS72271 CCDS72272
HPRD
IMGT
MGI ID MGI:101877
MGI Symbol Tcf12
EMBL AC093483 AC157575 AC159001
GenPept
RNA Seq Atlas 21406

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca