InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bax

Summary

InnateDB Gene

IDBG-183241.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bax

Gene Name

BCL2-associated X protein

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003873

Encoded Proteins

IDBP-183243

BCL2-associated X protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087088:
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:45461695-45466898

Strand

Reverse strand

Band

Transcripts

ENSMUST00000033093

ENSMUSP00000033093

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	35 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	79 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0015267	channel activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051434	BH3 domain binding

Biological Process

GO:0001541	ovarian follicle development
GO:0001764	neuron migration
GO:0001776	leukocyte homeostasis
GO:0001777	T cell homeostatic proliferation
GO:0001782	B cell homeostasis
GO:0001783	B cell apoptotic process
GO:0001822	kidney development
GO:0001836	release of cytochrome c from mitochondria
GO:0001844	protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001974	blood vessel remodeling
GO:0002262	myeloid cell homeostasis
GO:0002352	B cell negative selection
GO:0002358	B cell homeostatic proliferation
GO:0002904	positive regulation of B cell apoptotic process
GO:0006687	glycosphingolipid metabolic process
GO:0006808	regulation of nitrogen utilization
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006927	transformed cell apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0007281	germ cell development
GO:0007283	spermatogenesis
GO:0007399	nervous system development
GO:0007548	sex differentiation
GO:0008053	mitochondrial fusion
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008637	apoptotic mitochondrial changes
GO:0009566	fertilization
GO:0009611	response to wounding
GO:0009636	response to toxic substance
GO:0009651	response to salt stress
GO:0009791	post-embryonic development
GO:0010212	response to ionizing radiation
GO:0010248	establishment or maintenance of transmembrane electrochemical gradient
GO:0010332	response to gamma radiation
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0021854	hypothalamus development
GO:0021987	cerebral cortex development
GO:0032091	negative regulation of protein binding
GO:0032461	positive regulation of protein oligomerization
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
GO:0032976	release of matrix enzymes from mitochondria
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0033599	regulation of mammary gland epithelial cell proliferation
GO:0034644	cellular response to UV
GO:0035108	limb morphogenesis
GO:0035234	ectopic germ cell programmed cell death
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043496	regulation of protein homodimerization activity
GO:0043497	regulation of protein heterodimerization activity
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0043653	mitochondrial fragmentation involved in apoptotic process
GO:0045136	development of secondary sexual characteristics
GO:0046666	retinal cell programmed cell death
GO:0048087	positive regulation of developmental pigmentation
GO:0048147	negative regulation of fibroblast proliferation
GO:0048515	spermatid differentiation
GO:0048597	post-embryonic camera-type eye morphogenesis
GO:0048678	response to axon injury
GO:0048872	homeostasis of number of cells
GO:0048873	homeostasis of number of cells within a tissue
GO:0051259	protein oligomerization
GO:0051260	protein homooligomerization
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051402	neuron apoptotic process
GO:0051726	regulation of cell cycle
GO:0051881	regulation of mitochondrial membrane potential
GO:0060011	Sertoli cell proliferation
GO:0060041	retina development in camera-type eye
GO:0060058	positive regulation of apoptotic process involved in mammary gland involution
GO:0060068	vagina development
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070242	thymocyte apoptotic process
GO:0070584	mitochondrion morphogenesis
GO:0071310	cellular response to organic substance
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193	intrinsic apoptotic signaling pathway
GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response
GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902110	positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902262	apoptotic process involved in patterning of blood vessels
GO:1902263	apoptotic process involved in embryonic digit morphogenesis
GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO:1902512	positive regulation of apoptotic DNA fragmentation
GO:1990009	retinal cell apoptotic process
GO:1990117	B cell receptor apoptotic signaling pathway
GO:2001234	negative regulation of apoptotic signaling pathway
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005757	mitochondrial permeability transition pore complex
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane
GO:0046930	pore complex
GO:0070062	extracellular vesicular exosome
GO:0097136	Bcl-2 family protein complex
GO:0097144	BAX complex