Version 5.4
Mus musculus Gene: Rab27a
Summary
InnateDB Gene IDBG-184264.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rab27a
Gene Name RAB27A, member RAS oncogene family
Synonyms 2210402C08Rik; 2410003M20Rik; 4933437C11Rik; ash
Species Mus musculus
Ensembl Gene ENSMUSG00000032202
Encoded Proteins
IDBP-184266
RAB27A, member RAS oncogene family
IDBP-787776
RAB27A, member RAS oncogene family
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the Rab family of proteins, which is the largest family within the Ras superfamily of GTPases. This gene product is thought to regulate vesicular transport, together with its specific effectors. Mutations in this gene cause several defects, including actin-based melanosome transport defects and immunodeficiency. Mutations in the human ortholog of this gene are associated with Griscelli syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:73044854-73097629
Strand Forward strand
Band D
Transcripts
ENSMUST00000034722 ENSMUSP00000034722
ENSMUST00000184146 ENSMUSP00000139310
ENSMUST00000184575
ENSMUST00000184032
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0019904 protein domain specific binding
GO:0031489 myosin V binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006605 protein targeting
GO:0006886 intracellular protein transport
GO:0006887 exocytosis
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007596 blood coagulation
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0019882 antigen processing and presentation
GO:0030318 melanocyte differentiation
GO:0032400 melanosome localization
GO:0032402 melanosome transport
GO:0043316 cytotoxic T cell degranulation
GO:0043320 natural killer cell degranulation
GO:0043473 pigmentation
GO:0045921 positive regulation of exocytosis
GO:0051875 pigment granule localization
GO:0051904 pigment granule transport
GO:0071985 multivesicular body sorting pathway
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005622 intracellular
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0030141 secretory granule
GO:0030425 dendrite
GO:0030667 secretory granule membrane
GO:0032585 multivesicular body membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
GO:0070382 exocytic vesicle
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000069974
View Gene Order
Pathways
NETPATH
REACTOME
REACT_247926
Metabolism of proteins pathway
REACT_206913
Peptide hormone metabolism pathway
REACT_207837
Insulin processing pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15550
Insulin processing pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_023635 XM_006510780 XM_006510781 XM_006510782
OMIM
CCDS CCDS23335
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca