InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ace2

Summary

InnateDB Gene

IDBG-184519.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ace2

Gene Name

angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

Synonyms

2010305L05Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015405

Encoded Proteins

IDBP-184521

angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

IDBP-256354

angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

IDBP-536243

angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22837003

Ace2 deficiency results in increased susceptibility to intestinal inflammation induced by epithelial damage. Ace2 links amino acid malnutrition to altered gut microbiota, which leads to colitis susceptibility.

InnateDB Annotation from Orthologs

Summary

PMID 22837003

[Homo sapiens] ACE2 deficiency results in increased susceptibility to intestinal inflammation induced by epithelial damage. ACE2 links amino acid malnutrition to altered gut microbiota, which leads to colitis susceptibility. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130234:
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:164139332-164188420

Strand

Forward strand

Band

Transcripts

ENSMUST00000073973	ENSMUSP00000073626
ENSMUST00000112271	ENSMUSP00000107890
ENSMUST00000131543	ENSMUSP00000123313

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0001948	glycoprotein binding
GO:0004175	endopeptidase activity
GO:0004180	carboxypeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008241	peptidyl-dipeptidase activity
GO:0017046	peptide hormone binding
GO:0042277	peptide binding
GO:0046872	metal ion binding

Biological Process

GO:0003051	angiotensin-mediated drinking behavior
GO:0006508	proteolysis
GO:0009615	response to virus
GO:0032800	receptor biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0046813	receptor-mediated virion attachment to host cell
GO:0060135	maternal process involved in female pregnancy

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome